The New Review “The testis: an accessible Mesenchymal Stem Cells source” is now published online!

About the author:

 

Asma Amleh is an associate professor of biology at The American University in Cairo, Egypt. She received a BSc in biology and chemistry at The American University of Beirut, Lebanon (1983), and a PhD in biology from McGill University in Montreal, Canada (1997).

 

Professor Amleh has been a research fellow at the laboratory of cellular and developmental biology, NIDDK, and a research associate at the National Institutes of Health, Bethesda, MD, USA.  She has also been an instructor at the Department of Molecular Medicine, Institute of Biotechnology, at the University of Texas Health Science Center and a senior research scientist at the Developmental Biology Program, Memorial Sloan-Kettering Cancer Center in NY.

 

Her research interests focus on Defining genetic markers implicated in the development of hepatocellular carcinoma, which represents a burden on the Egyptian society, Exploring a novel non-conventional approach to reducing Pt-based drug resistance and thus improving cancer patients' survival, and Characterizing the bioactivity of newly synthesized biomaterial intended for developing implants.

 

About the review:

 

Abstract

 

Mesenchymal stem cells (MSCs) are adult stem cells mainly found in the bone marrow but are also present in several other tissues, such as cord blood, peripheral blood, lungs and adipose tissue. Recently, several groups have also identified and isolated MSCs from primary cultures of human testes. MSCs are considered multipotent cells that can differentiate to form adipocytes, bone, cartilage, skin, and muscle. This potential to differentiate into multiple cell types has elicited much attention, since they appear to hold great promise in regard to regenerative cell-based therapy for the treatment of various diseases, including cancer. They are considered powerful allogenic nonhematopoietic transplantation stem cells due to their low immunogenicity. This review aimed to highlight the latest advances in the study of the biological properties and characteristics of MSCs, with a focus on testicular mesenchymal stromal stem cells, their differentiation capacity and immunosuppressive properties, which could make them powerful therapeutic agents, especially for cancer patients.

 

Keywords

 

Testicular mesenchymal stromal stem cells, MSC sources, MSC isolation, Multilineage potential, Cancer therapeutic application

 

We warmly welcome any opinions on this review!