Proton therapy – An evolving technology

Antonio Cassio Assis Pellizzon

Abstract


In the last 25 years, more effective chemotherapy, better surgical and radiotherapy techniques have contributed, at least in part, to improvement in control for most cancers, also increasing the number of patients referred for a second course of radiation.

Keywords


radiation therapy; protons; re-irradiation; treatment cost; quality of life; cancer

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References


Greenlee RT, Murray T, Bolden S, Wingo PA. Cancer statistics. CA Cancer J Clin 2000; 50(1): 7–33. doi: 10.3322/canjclin.50.1.7.

Fowler JF. What can we expect from dose escalation using proton beams? Clin Oncol 2003; 15(1):S10–S15. doi: 10.1053/clon.2002.0182.

Raju MR. Proton radiobiology, radiosurgery and radiotherapy. Int J Radiat Biol 1995; 67(3): 237–259. doi: 10.1080/09553009514550301.

Wieszczycka W, Scharf WH. Proton radiotherapy accelerators. Singapore: World Scientific Publishing Co. Pte. Ltd.; 2001. p. 203–217. doi: 10.1142/9789812811646_0008.

Huff C. Catching the proton wave [Internet]. McLean, Virginia, USA: The National Association for Proton Therapy [cited 2017 Aug 01]. Available from: http://www.proton-therapy.org/hhnarticle.htm.

Iversen G. Proton therapy: progress with a price tag [Internet]. McLean, Virginia, USA: The National Association for Proton Therapy [cited 2017 Jul 31]. Available from: http://proton-therapy.org/dotmed_progress_sept_2014.html.

Hagan WK, Colborn BL, Armstrong TW, Allen M. Radiation shielding calculations for a 70- to 250-MeV proton therapy facility. Nucl Sci Eng 1988; 98(3): 272–278.

Nafziger B. Protontherapy: Can you afford it? [Internet] McLean, Virginia, USA: The National Association for Proton Therapy [cited yyyy mmm dd]. Available from: http://www.proton-therapy.org/documents/dotmed511.pdf.

Imaging Technology News. Proton Therapy World Market Expected to Reach $1 Billion in 2019 [Internet]. Arlington Heights, IL, USA: Scranton Gillette Communications [cited 2017 Aug 01]. Available from: https://www.itnonline.com/article/proton-therapy-world-market-expected-reach-1-billion-2019.

Pedroni E, Scheib S, Böhringer T, Coray A, Grossmann M, et al. Experimental characterization and physical modelling of the dose distribution of scanned proton pencil beams. Phys Med Biol 2005; 50(3): 541–561. doi: 10.1088/0031-9155/50/3/011.

Moteabbed M, Yock TI, Depauw N, Madden TM, Kooy HM, et al. Impact of spot size and beam-shaping devices on the treatment plan quality for pencil beam scanning proton therapy. Int J Radiat Oncol Biol Phys 2016; 95(1): 190–198. doi: 10.1016/j.ijrobp.2015.12.368.

Mouw KW, Yeap BY, Caruso P, Fay A, Misra M, et al. Analysis of patient outcomes following proton radiation therapy for retinoblastoma. Adv Radiat Oncol 2017; 2(1): 44–52. doi: 10.1016/j.adro.2016.11.002.

Romesser PB, Cahlon O, Scher E, Zhou Y, Berry SL, et al. Proton beam radiation therapy results in significantly reduced toxicity compared with intensity-modulated radiation therapy for head and neck tumors that require ipsilateral radiation. Radiother Oncol 2016; 118(2): 286–292. doi: 10.1016/j.radonc.2015.12.008.

Schneider U, Lomax A, Lombriser N. Comparative risk assessment of secondary cancer incidence after treatment of Hodgkin’s disease with photon and proton radiation. Radiat Res 2000; 154(4): 382–388. doi: 10.1667/0033-7587(2000)154[0382:CRAOSC]2.0.CO;2.

Mayahara H, Murakami M, Kagawa K, Kawaguchi A, Oda Y, et al. Acute morbidity of proton therapy for prostate cancer: The Hyogo ion beam medical center experience. Int J Radiat Oncol Biol Phys 2007; 69(2): 434–443. doi: 10.1016/j.ijrobp.2007.03.009.

Bradley JA, Dagan R, Ho MW, Rutenberg M, Morris CG, et al. Initial report of a prospective dosimetric and clinical feasibility trial demonstrates the potential of protons to increase the therapeutic ratio in breast cancer compared with photons. Int J Radiat Oncol Biol Phys 2016; 95(1): 411–421. doi: 10.1016/j.ijrobp.2015.09.018.

Armoogum KS, Thorp N. Dosimetric comparison and potential for improved clinical outcomes of paediatric CNS patients treated with protons or IMRT. Cancers 2015; 7(2): 706–722. doi: 10.3390/cancers7020706.

Sanchez-Parcerisa D, Kirk M, Fager M, Burgdorf B, Stowe M, et al. Range optimization for mono- and bi-energetic proton modulated arc therapy with pencil beam scanning. Phys Med Biol 2016; 61(21): N565–N574. doi: https://doi.org/10.1088/0031-9155/61/21/N565.

American Society for Radiation Oncology (ASTRO). Proton beam therapy (PBT) [Internet]. Arlington, Virginia, USA: ASTRO [cited 2017 Aug 01]. Available from: https://www.astro.org/uploadedFiles/Main_Site/Practice_Management/Reimbursement/ASTRO%20PBT%20Model%20Policy%20FINAL.pdf.




DOI: http://dx.doi.org/10.30564/amor.v3i4.127

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