Open Journal Systems

The hope of modulating microbiome in the management of cancer patients

Rita S. Cheng ()
Kwong-Kwok Wong ()


Human beings harbor tens of trillions of bacteria in their bodies...


bacteria; microbiota; immunotherapy

Full Text:



Sender R, Fuchs S, Milo R. Revised estimates for the number of human and bacteria cells in the body. PLoS Biol 2016; 14(8): e1002533. doi: 10.1371/journal.pbio.1002533.

Qin J, Li R, Raes J, Arumugam M, Burgdorf KS et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010; 464(7285): 59–65. doi: 10.1038/nature08821.

David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 2014; 505(7484): 559–563. doi: 10.1038/nature12820.

So WKW, Law BMH, Law PTW, Choi KC, Chan CWH. A pilot study to compare two types of heat-stabilized rice bran in modifying compositions of intestinal microbiota among healthy Chinese adults. Adv Mod Oncol Res 2018; 4(1): 1–16. doi: 10.18282/amor.v4.i1.253.

Chaput N, Lepage P, Coutzac C, Soularue E, Le Roux K et al. Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab. Ann Oncol 2017; 28(6): 1368–1379. doi: 10.1093/annonc/mdx108.

Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science 2018; 359(6371): 91–97. doi: 10.1126/science.aan3706.

Gopalakrishnan V, Spencer CN, Nezi L, Reuben A, Andrews MC et al. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science 2018; 359(6371): 97–103. doi: 10.1126/science.aan4236.

Matson V, Fessler J, Bao R, Chongsuwat T, Zha Y et al. The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients. Science 2018; 359(6371): 104–108. doi: 10.1126/science.aao3290.

Rosshart SP, Vassallo BG, Angeletti D, Hutchinson DS, Morgan AP et al. Wild mouse gut microbiota promotes host fitness and improves disease resistance. Cell 2017; 171(5): 1015–1028. doi: 10.1016/j.cell.2017.09.016.

Geller LT, Barzily-Rokni M, Danino T, Jonas OH, Shental N et al. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science 2017; 357(6356): 1156–1160. doi: 10.1126/science.aah5043.

Pushalkar S, Hundeyin M, Daley D, Zambirinis CP, Kurz E et al. The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression. Cancer Discov 2018. doi: 10.1158/2159-8290.CD-17-1134.

Browne HP, Forster SC, Anonye BO, Kumar N, Neville BA et al. Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation. Nature 2016; 533(7604): 543–546. doi: 10.1038/nature17645.

Franzosa EA, Morgan XC, Segata N, Waldron L, Reyes J et al. Relating the metatranscriptome and metagenome of the human gut. Proc Natl Acad Sci USA 2014; 111(22): E2329–2338. doi: 10.1073/pnas.1319284111.



  • There are currently no refbacks.

Copyright (c) 2018 Rita S. Cheng, Kwong-Kwok Wong

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.