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Prognostic factors analysis of conventional radiotherapy for postoperative breast cancer in 247 cases

Jing Zhu ()
Hua Jin ()

Abstract

Objective: To investigate the prognostic factors of postoperative radiotherapy for breast cancer in 247 cases. Methods: Retrospective study included 247 patients with breast cancer postoperative radiotherapy at the First Hospital of China Medical University from August 2008 to Jan- uary 2015. Patients clinical data and blood routines before radiotherapy were collected. The median was used to the cut-off values for red blood cell count(RBC). Kaplan-Meier method was used to obtain 5-year DFS and OS, Log-rank method for univariate analysis and Cox regression model for multivariate analysis. P＜0.05 represents a statistically significant. Results: Among the 247 patients, RBC before radiotherapy was statistically signif- icant in univariate (P=0.036) and multivariate analysis of DFS (P=0.036, HR: 0.518, 95%CI:0.280-0.958). Histological grade, N stage, ER state and HER2 stage were statistically significant in univariate and multivariate analysis of OS (P=0.005、0.003、0.015 and 0.010 respectively). Conclusion: PLR before radiotherapy was independent prognostic factors for DFS in breast cancer radiotherapy. Histological grade, N stage, ER state and HER2 stage were independent prognostic factors for OS in breast cancer radiotherapy.

Keywords

Red blood cell count; Breast cancer radiotherapy; Prognosis

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References

Chen Wan Qing, Zhang Si Wei, Zeng Hong Mei, etc. mortality and morbidity of malignant tumor in China 2010 [J]. China Cancer,2014(1):1-10.

Bloomfield CD, McKenna RW, Brunning RD. Signifikin's malignant lymphomas[J]. Br J Haematol, 1976 Jan, 32 (1):41-46.

Sejima T, Morizane S, Yao A, et al. Prognostic im- pact of preoperative hematological disorders and a risk stratification model in bladder cancer pa- tients treated with radical cystectomy[J]. Int J Urol, 2014 Jan,21(1):52-57.

Hirahara N, Matsubara T, Kawahara D, et al. Prognos- tic value of blood routine parameter in patients un- dergoing esophagectomy for esophageal squamous cell carcinoma[J]. Int J Clin Oncol. 2016 Oct, 21(5): 909- 919.

Eggemann H, Ehricke J, Ignatov T, et al. Platelet Count After Chemotherapy is a Predictor for Outcome for Ovarian Cancer Patient[J]. Cancer Invest, 2015 May,33(5):193-196.

Hong X, Cui B, Wang M, et al. Systemic Immune-in-flammation Index,Based on Platelet Counts and Neu-trophil-Lymphocyte Ratio, Is Useful for Predicting Prognosis in Small Cell Lung Cancer[J]. Tohoku J Exp Med, 2015 Aug: 236(4):297-304.

Hong X, Cui B, Wang M, et al.Systemic Immune-inflam-mation Index, Based on Platelet Counts and Neutrophil-Lymphocyte Ratio, Is Useful for Predicting Prognosis in Small Cell Lung Cancer[J].Tohoku J Exp Med, 2015 Aug,236(4):297-304.

Azab B, Bhatt VR, Phookan J, et al. Usefulness of the neutrophil-to-lymphocyte ratio in predicting short- and long-term mortality in breast cancer patients[J]. Ann Surg Oncol, 2012 Jan,19(1):217-224.

Azab B, Shah N, Radbel J, et al. Pretreatment neutrophil/lymphocyte ratio is superior to platelet / lymphocyte ratio as a predictor of long-term mortality in breast cancer patients[J]. Med Oncol, 2013 Mar,30(1):432.

Dirican A, Kucukzeybek BB, Alacacioglu A, et al. Do the derived neutrophil to lymphocyte ratio and the neutrophil to lymphocyte ratio predict prognosis in breast cancer?[J]. Int J Clin Oncol, 2015 Feb,20(1):70-81.

Koh CH, Bhoo-Pathy N, Ng KL, et al. Utility of pretreatment neutrophil-lymphocyte ratio and plateletlymphocyte ratio as prognostic factors in breast cancer[J]. Br J Cancer, 2015 Jun 30, 113(1):150-158.

Jia W, Wu J, Jia H, et al. The Peripheral Blood Neutrophil-To-Lymphocyte Ratio Is Superior to the Lymphocyte-To-Monocyte Ratio for Predicting the LongTerm Survival of Triple-Negative Breast Cancer Patients[J]. PLoS One, 2015,10(11): e0143061.

Hong J, Mao Y, Chen X, et al. Elevated preoperative neutrophil-to-lymphocyte ratio predicts poor disease-free survival in Chinese women with breast cancer[J]. Tumor Biology, 2016 Mar, 37(3):4135-4142.

Asano Y, Kashiwagi S, Onoda N, et al. Platelet-Lym -phocyte Ratio as a Useful Predictor of the Therapeutic Effect of Neoadjuvant Chemotherapy in Breast Cancer[J]. PLoS One, 2016 Jul 29,11(7):e0153459.

Krenn-Pilko S, Langsenlehner U, Thurner EM, et al. The elevated preoperative platelet-to-lymphocyte ratio predicts poor prognosis in breast cancer patients[J]. Br J Cancer, 2014 May 13,110(10):2524-2530.

Zhu Y, Si W, Sun Q, et al. Platelet-lymphocyte ratio acts as an indicator of poor prognosis in patients with breast cancer[J]. Oncotarget, 2017 Jan 3,8(1):1023-1030.

J i H, Xuan Q, Yan C, et al. The prognostic and predictive value of the lymphocyte to monocyte ratio in luminal-type breast cancer patients treated with CEF chemotherapy[J]. Oncotarget, 2016, 7(23): 34881-34889.

Taucher S, Salat A, Gnant M, et al. Impact of pretreatment thrombocytosis on survival in primary breast cancer[J]. Thromb Haemost, 2003 Jun, 89(6):1098-1106.

Wen J, Ye F, Huang X, et al. Prognostic Significance of Preoperative Circulating Monocyte Count in Patients With Breast Cancer: Based on a Large Cohort Study[J]. Medicine (Baltimore), 2015 Dec, 94(49):e2266.

Gu M, Zhai Z, Huang L, et al. Pre-treatment mean platelet volume associates with worse clinicopatho logic features and prognosis of patients with invasive breast cancer[J]. Breast Cancer, 2016 Sep, 23(5):752-760.

Gündüz S, Göksu SS, Arslan D, et al. Factors affecting disease-free survival in patients with human epidermal growth factor receptor 2-positive breast cancer who receive adjuvant trastuzumab[J]. Mol Clin Oncol, 2015 Sep,3(5):1109–1112.

Tatum JL, Kelloff GJ, Gillies RJ, et al. Hypoxia: Importance in tumor biology, noninvasive measurement by imaging and value of its measurement in the management of cancer therapy[J]. Int J Radiat Biol, 2006,82(10):699-757,

Harris AL. Hypoxia-a key regulatory factor in tumour growth[J]. Nat Rev Cancer, 2002 Jan,2(1):38-47.

Nordsmark M, Overgaard M, Overgaard J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck[J]. Radiother Oncol, 1996,41(1):31-39.

Vaupel P and Mayer A. Hypoxia in cancer: Significance and impact on clinical outcome[J]. Cancer Metastasis, 2007,26(18):225-239.

Fyles A, Milosevic M, Hedley D, et al. Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer[J]. J Clin Oncol, 2002,20(3):680-687.

DOI: http://dx.doi.org/10.30564/amor.v4i3.178

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