Clinical application of lobaplatin combined with docetaxel in adjuvant chemotherapy for triple-negative breast cancer in elderly patients

Weihua Jiang, Li Wang, Yongtao Li, Chenguang Zhang, Lina Yi, Jianghua Ou

Abstract


 

Abstract: Objective: To investigate the adverse reactions and efficacy of docetaxel combined with lobaplatin in adjuvant chemotherapy for triple-negative breast cancer in elderly patients. Methods: A total of 96 elderly triple-negative breast cancer patients admitted to our hospital from January 2008 to December 2011 were randomly divided into two groups. A group of 56 patients received docetaxel 75 mg·m-2, intravenous drip, d1; lobaplatin 30 mg·m-2,intravenous drip, d1; 21 days repeat, a total of 6 cycles. A group of 40 patients received chemotherapy for 6 cycles with an anthracycline-containing (TEC) regimen. Comparison of adverse reactions and 5-year disease-free survival in both groups. Results: The incidence of thrombocytopenia was significantly higher in 56 patients with TL regimen than those with TCE-containing anthracyclines (P=0.005). But the incidence of cardiotoxicity was 32.5% in the TEC group. And the difference was statistically significant (P=0.008). The 5-year disease-free survival rate was 73.2% in the TL group and 67.5% in the TEC group. There was no statistical difference. Conclusion: Docetaxel combined with lobaplatin in the treatment of elderly triple-negative breast cancer has no significant difference in efficacy compared with traditional anthracycline-containing drugs, but it can avoid the cardiotoxicity caused by anthracyclines. It’s a new option for elderly TNBC adjuvant chemotherapy, suggesting to expand the sample content for further research. 


Keywords


Docetaxel; Lobaplatin; Triple-negative breast cancer

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DOI: http://dx.doi.org/10.30564/amor.v6i1.215

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