Photothermal and Chemotherapy Combined Therapy of B-CuS-DOX Based on/pH Dual Stimulation

Sheikh Sajjad Ahmed, Zhong Deng

Abstract


Single chemotherapy is difficult to meet the needs of tumor cure. Photothermia combined with chemotherapy is a new and effective anti-tumor therapy. However, the drug loading of nanoparticles and increase in performance of photothermal conversion limits the therapeutic effect of combination therapy. In this study, two-dimensional boron (boron, B) nanoparticles were prepared by ultrasonic exfoliation, and copper sulfide (CuS) nanoparticles and doxorubicin (DOX) were grown on the surface of the nanoparticles to form B-CuS-DOX nanoparticles. B-CuS carrier has high DOX drug loading capacity (864mg/g) and good photothermal conversion performance (photothermal conversion efficiency at 808nm is 55.8%). At the same time, it can achieve drug release and good photothermal response at near infrared and pH. The nanoparticles designed in this study are expected to provide an effective chemotherapy-photothermal therapy strategy for tumor therapy in vivo.


Keywords


Combination therapy; Chemotherapy; Photothermal therapy; Stimulus response release

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References


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DOI: http://dx.doi.org/10.30564/amor.v5i1.222

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