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Photothermal and Chemotherapy Combined Therapy of B-CuS-DOX Based on/pH Dual Stimulation

Sheikh Sajjad Ahmed (World College of Medical Sciences & Research and Hospital Kashmir, Pakistan)
Zhong Deng (China Basic Medicine Institute Beijing, China)


Single chemotherapy is difficult to meet the needs of tumor cure. Photothermia combined with chemotherapy is a new and effective anti-tumor therapy. However, the drug loading of nanoparticles and increase in performance of photothermal conversion limits the therapeutic effect of combination therapy. In this study, two-dimensional boron (boron, B) nanoparticles were prepared by ultrasonic exfoliation, and copper sulfide (CuS) nanoparticles and doxorubicin (DOX) were grown on the surface of the nanoparticles to form B-CuS-DOX nanoparticles. B-CuS carrier has high DOX drug loading capacity (864mg/g) and good photothermal conversion performance (photothermal conversion efficiency at 808nm is 55.8%). At the same time, it can achieve drug release and good photothermal response at near infrared and pH. The nanoparticles designed in this study are expected to provide an effective chemotherapy-photothermal therapy strategy for tumor therapy in vivo.


Combination therapy; Chemotherapy; Photothermal therapy; Stimulus response release

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FU F F, WU Y L, ZHU J Y, et al. Multifunctional lactobionic acid-modified dendrimers for targeted drug delivery to liver cancer cells: investigating the role played by PEG spacer. ACS Applied Materials & Interfaces, 2014, 6(18) :16416-16425.

SCHILLER JH, HARRINGTON D, BELANI CP, et al.Comparison of four chemotherapy regimens for advanced non–small-cell lung cancer. New England Journal of Medicine, 2002,346(2):92-98.

SHAO T P, WEN J, ZHANG Q, et al. NIR photo-responsive drug delivery and synergistic chemo-photothermal therapy by monodispersed MoS2 nanosheets wrapped periodic mesoporous organosilicas.Journal of materals chemistry B,2016,4(47):1-26.

SUN H, CHANG R, ZOU Q, et al. Supramolecular protein nanodrugs with coordi nation and heating‐enhanced photothermal effects for antitumor therapy. Small, 2019, 15(52):1905326.

ZHENG M B, YUE C X, MA Y F, et al. Single-step assembly of DOX/ICG loaded lipid polymer nanoparticles for highly effective chemo-photothermal combination therapy. ACS Nano, 2013,7(3):2056-2067.

Zhang Z, Wang J, Chen C. Near-Infrared Light-Mediated Nanoplatforms For Cancer Thermo-Chemotherapy And Optical Imaging [J]. Advanced Materials, 2013, 25(28): 3869-3880.

Li Z, Hu Y, Howard K A, Et Al. Multifunctional Bismuth Selenide Nanocomposites For Antitumor Thermo-Chemotherapy And Imaging [J]. Acs Nano, 2016, 10(1): 984-997.

Wang L, Sun Q, Wang X, Et Al. Using Hollow Carbon Nanospheres As A Light-Induced Free Radical Generator To Overcome Chemotherapy Resistance [J]. Journal Of The American Chemical Society, 2015, 137(5): 1947-1955.

Saadeh Y, Leung T, Vyas A, Et Al. Applications Of Nanomedicine In Breast Cancer Detection, Imaging, And Therapy [J]. Journal Of Nanoscience & Nanotechnology, 2014, 14(1): 913-923.

Zhou J, Wang Z, Li Q, Et Al. Hybridized Doxorubicin-Au Nanospheres Exhibit Enhanced Near-Infrared Surface Plasmon Absorption For Photothermal Therapy Applications [J]. Nanoscale, 2015, 7(13): 5869-5883.

Hervault A, Dunn A E, Lim M, Et Al. Doxorubicin Loaded Dual Ph- And Thermo-Responsive Magnetic Nanocarrier For Combined Magnetic Hyperthermia And Targeted Controlled Drug Delivery Applications [J]. Nanoscale, 2016, 8(24): 12152-12161.

Liu Yi, Bian Yuan, Ye Yun. Adriamycin Antitumor Effects [J]: 101-103. Journal of Luzhou Medical College, 2008, 31 (1): 101-103.

Wynendaele W, Morales L, Christiaens M R, Et Al. Promising Clinical And Pathological Response Rates With Neoadjuvant Sequential Doxorubicine (Dox) And Docetaxel (Doc) In Locally Advanced Breast Cancer (Labc) [J]. European Journal Of Cancer, 2002, 38(5): 66-66.

Yan F, Duan W, Li Y, Et Al. Nir-Laser-Controlled Drug Release From Dox/Ir-780-Loaded Temperature-Sensitive-Liposomes For Chemo-Photothermal Synergistic Tumor Therapy [J]. Theranostics, 2016, 6(13): 2337-2351.

Yan Z, Zheng Y, Zhao C, Et Al. Hollow Pda-Au Nanoparticles-Enabled Signal Amplification For Sensitive Nonenzymatic Colorimetric Immunodetection Of Carbohydrate Antigen 125 [J]. Biosensors & Bioelectronics, 2015, 71(15): 200-206.

Shanmugam V, Selvakumar S, Yeh C S. Near-Infrared Light-Responsive Nanomaterials In Cancer Therapeutics [J]. Chemical Society Reviews, 2014, 43(17): 6254-6287.

Wang F, Wang Y C, Dou S, Et Al. Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery For Overcoming Multidrug Resistance In Cancer Cells [J]. Acs Nano, 2011, 5(5): 3679-3692.

Jiang X M, Wang L M, Wang J, Et Al. Gold Nanomaterials: Preparation, Chemical Modification, Biomedical Applications And Potential Risk Assessment [J]. Applied Biochemistry & Biotechnology, 2012, 166(6): 1533-1551.

Ghosh P, Han G, De M, Et Al. Gold Nanoparticles In Delivery Applications [J]. Advanced Drug Delivery Reviews, 2008, 60(11): 1307.



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