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To Explore the Correlation between Tumor and Immune Markers and HPV Expression and Prognosis in Patients with Cervical Cancer

Ezalia Bt. Isa (Diabetes & Endocrine ,Medical University of Malaysia,Malaysia)
Xiangyang Zhu (Institute of Radiation Medicine, Chinese Academy of Sciences,Shanghai, China)


The aim of this study was to investigate the correlation between immune cells and tumor markers and HPV levels in patients with cervical cancer with high-risk human papilloma virus (HPV) rate and their prognosis. Firstly, 83 cases of cervical intraepithelial neoplasia were selected as CINI group, 72 cases of cervical carcinoma as cervical cancer group and 50 cases of chronic cervicitis as chronic cervicitis group. The different expression levels of immune cells (CD4+, CD8+, Treg, CD4+/CD8+, CD56+,) and the positive expression of tumor markers (K-ras, Ki-67) inpatients with HPV were studied to explore the correlation between HPV levels and immune cells and tumor markers in cervical cancer patients with high-risk HPV infection, and that between positive expression of immune cells and tumor markers in patients with lymph node metastasis of cervical cancer with high-risk HPV infection, as well as that between the survival rate of patients and the immune cell levels and positive expression of tumor markers in patients who die of cervical cancer. The results showed that the levels of CD8 + and Treg in cervical cancer patients were higher than those in CIN group and chronic cervicitis group (P < 0.05). The levels of tumor markers were lower in those in CIN group and chronic cervicitis group (P < 0.05). The positive expression rates of K-ras and KI-67 in the three groups were significantly different (P < 0.05). In cervical cancer group, CD4 + and CD56+ were negatively correlated with HPV-DNA levels, and CD8 + and Treg levels as well as k-RAS and KI-67 positive expression were positively correlated with HPV-DNA levels. The levels of immune markers in cervical cancer group were significantly lower than those in surviving patients (P < 0.01), while the levels of CD8 + and Treg, the proportion of K-RA and KI-67 were significantly higher than those in surviving patients (P < 0.01). Therefore, for patients with CIN, chronic cervicitis patients with high-risk HPV infection, and cervical cancer patients with reduced immune function and high-risk HPV infection, the expression of tumor markers K-ras and Ki-67 was increased. The detection of immune cells and tumor markers is helpful for the early prevention, diagnosis and prognosis evaluation of high-risk HPV infection in patients with cervical cancer.


HPV diagnosis; Prognosis; Immune cells; Tumor markers

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