Phycocyanin/polysaccharide of spirulina platensis for antitumor immune activity

Langanani Mbodi, Ibtisam Abdullah

Abstract


Phycocyanin (PC) and polysaccharides from spirulina plantensis (PSP) are immune active substances with great anti-tumor potential. The antitumor immune activities of PC and PSP were studied in this paper. The antitumor immune activities of alginate and polysaccharide were detected by ELISA, MTT assay and quantitative hemolysis spectrophotometry at the levels of immune organs, immune cells and immune molecules. The results showed that the tumor diameter and tumor mass of mice treated with PC or PSP were smaller than those in the control group, the activity of T cells and B cells was also significantly enhanced, and the number of humoral antibodies was significantly increased. The effect of PS on tumor cell growth and immunity was more obvious than that of PSP.

Full Text:

PDF

References


Khan Z , Bhadouria P , Bisen P . Nutritional and Therapeutic Potential of Spirulina[J]. Curr Pharm Biotechnol, 2005, 6(5):-.

Eriksen N T . Production of phycocyanin--a pigment with applications in biology, biotechnology, foods and medicine.[J]. Applied Microbiology & Biotechnology, 2008, 80(1):1.

Ciferri O , Tiboni O . The biochemistry and industrial potential of Spirulina.[J]. Annual Review of Microbiology, 1985, 39(1):503-526.

Plantensis S . The determination of polysaccharide of Spirulina Plantensis by agarose gel electrophoresis[J]. Chinese Journal of Biochemical Pharmaceutics, 2003.

Xin C , Hong-Ping Y , Min W . Effect on Sulfate Content of Acidic Polysaccharides from Spirulina Platensis at Different pH Values[J]. Pharmaceutical Biotechnology, 2004.

Van M J , Kaspers G J , Cloos J . Cell Sensitivity Assays: The MTT Assay[J]. Methods Mol Biol, 2011, 88(88):237-245.

Ramey W G , Hashim G A , Burrows W B , et al. Detection of breast tumor antigen-sensitive circulating T-lymphocytes by antigen-stimulated active rosette formation[J]. Cancer Research, 1979, 39(12):4796-801.

Van M J , Kaspers G J , Cloos J . Cell Sensitivity Assays: The MTT Assay[J]. Methods Mol Biol, 2011, 88(88):237-245.

Postal M , Appenzeller S . The importance of cytokines and autoantibodies in depression[J]. Autoimmunity Reviews, 2015, 14(1):30-35.

Miyazawa Y , Murayama T , Ooya N , et al. Immunomodulation by a unicellular green algae (Chlorella pyrenoidosa) in tumor-bearing mice[J]. Journal of Ethnopharmacology, 1988,24(2):135-146.

Yuhong S , Pharmacy D O , Hospital F P , et al. Antitumor role of the extraction from spirulina in S180-tumor bearing mice[J]. China Medical Herald, 2015.




DOI: http://dx.doi.org/10.30564/amor.v5i2.237

Refbacks

  • There are currently no refbacks.


Copyright (c) 2020 Langanani Mbodi, Ibtisam Abdullah

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.