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Multiple Tumor Markers Detection for Correlation Diagnosis of Ovarian Cancer

Reubina Wadee (The Medical Oncology Centre of Rosebank, Johannesburg, South Africa)
Safa I.H Taha (Radiation Medicine Program, Stronach Regional Cancer Center, Newmarket, Canada)


The contents of serum CA125, alpha-fetoprotein (AFP) and CA199 and their diagnostic value in ovarian cancer were analyzed in this study. Firstly, 80 patients with ovarian malignant tumors from June 2019 to June 2020 in our hospital were included in the study group, and 80 patients with benign ovarian tumors were included in the control group during the same period. Serum levels and positive rates of CA125, AFP and CA199 were detected in both study group and control group. The expression levels of CA125, AFP and CA199 in the study group were all higher than those in the control group (P <0.05). The positive rate of AFP, CA199 and CA125 was 33.75%, 47.50% and 91.25% in study group, respectively. The joint detection positive rate was 92.50%. However, . The positive rate of CA125, AFP and CA199 was 23.75%, 0% and 11.25% in control group, and the joint detection positive rate was 28.75%. The positive rates of all indexes and the positive rates of comprehensive detection in the study group were higher than that in the control group (P < 0.05). Therefore, serum CA125, AFP and CA199 can be used as important indicators for the diagnosis of ovarian cancer.


Tumor markers; Joint diagnosis; Ovarian cancer

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