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Gold Nanorods-mediated Photothermal Therapy Guided by Vascular Interventional Radiation to Inhibit Cancer Metastasis

Nomusa Mashigo (Department of Anatomical Pathology, School of Pathology, University of the Witwatersrand / National Health Laboratory Service, Johannesburg, South Africa)
Reubina Wadee (Department of Pathology, Division of Haematology, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa)


The purpose of this study was to investigate the inhibitory effect of gold nanorods-mediated photothermal therapy on liver metastasis of colorectal cancer under the guidance of vascular interventional radiology. A total of 80 patients admitted to our hospital from February 2018 to February 2020 were selected and randomly divided into study group and control group with 40 cases each, among which the control group received 125I seed implantation combined with chemotherapy. On this basis, the study group were added the gold nanorods (AuNRs) to the photothermal therapy additionally. The clinical efficacy, postoperative complications and postoperative survival rates of the two groups were compared. The results showed that the total clinical effective rate was 82.5% in the study group, which was significantly better than 67.5% in the control group, and the difference was statistically significant (P<0.05). In addition, the incidence of leukocytosis, nausea, vomiting and delayed diarrhea in the study group was significantly lower than that in the control group, with statistically significant differences (P<0.05). There were no statistically significant differences in the proportion of elevated body temperature, liver dysfunction, or moderate liver pain between the two groups (P>0.05).Therefore, under the guidance of vascular interventional radiology, Au NRs are safe and effective materials for the treatment of liver metastasis of colorectal cancer, which can reduce complications and improve postoperative survival rates.


Selective radiotherapy; Photothermal treatment; Gold nanorods

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Liu H, Yang JH. New Advances in translational therapy for hepatic metastasis of colorectal cancer [J]. Journal of Hepatobiliary Surgery, 2012, 26(6):472-475.

Yu J, HM, Ouyang HZ. Clinical value of vascular interventional therapy in the comprehensive treatment of liver cancer [J]. World latest medical information abstracts, 2019,19 (A5):29-30.

Xu Jun, HK, Gao B. Research progress of gold nanorods combined with internal radiotherapy targeted tumor therapy [J]. Journal of interventional radiology, 2015,24 (6):540-543.

Shi LF, LZ. Study on consistency of efficacy evaluation of different efficacy evaluation criteria for hepatic metastasis of colon cancer [J]. Journal of PLA medical college, 2014,35 (1):25-27.

CAI JQ. Progress in diagnosis and treatment of colorectal cancer with liver metastasis [J]. Chinese journal of clinician, 2019,47 (8):886-888.

Zheng ZY, Chen JH, Cai RB, et al. Effect of radical resection in the treatment of colorectal cancer with liver metastasis and risk factor analysis of postoperative recurrence of liver metastasis [J]. Journal of the third military medical university, 2016,38 (6):623-628.

Li YM, Zhan WH, Han FH, et al. Prognostic factor analysis of surgical treatment of colorectal cancer with simultaneous liver metastasis [J]. Chinese journal of general surgery, 2005,20 (10):625-628.

Ren Yun, Wang WY, Huang GY, et al. Clinical efficacy and safety of I125 radiation seed implantation combined with TACE in the treatment of elderly colorectal cancer with liver metastasis [J]. Journal of tropical medicine, 2017,17(5) : 658-661685.

Liu RQ, JIA ZZ, Cao Huicun, et al. Yttrium -90 microspheres cannot be resected during therapeutic operation Application of yTTRIum-90 microspheres for hepatic metastasis of colorectal cancer with chemotherapeutic resistance: A Review of series of radio-embolization (VII)[J]. Journal of Interventional Radiology, 2016, 27(10):1003-1010.

Chen ZK, Yang Jing, Xie LH. Killing of gastric cancer SGC-7901 cells by near-infrared photohyperthermia mediated by gold nanometer bar and inducing apoptosis [J]. Cancer prevention and treatment studies, 2019,46 (10): 890-894.

Shen Lei, GAO Bin, He KW. Application of gold nanoparticles in radiotherapy of tumor: How to utilize gold nanowires for maximum effect [J]. Tissue engineering research in China, 2014,18 (39): 6369-6374.

Hou GW, Liu XF, Jiang NY, et al. New screening strategies and research progress of colorectal cancer [J]. Advances in modern biomedical science, 2015,15 (9):1772-1774.



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