Sensitive Detection of Multiple Tumor Markers for Early Tumor Diagnosis

Hai E Lu, HaoHong Li, XinJing Luo

Abstract


Tumor markers have a wide clinical applications for early tumor screening and diagnosis. In the study, the combined detection of serum tumor markers (SCC-Ag, CYFRA21-1, CEA, CA125, NSE) was used to explore the correlation and diagnostic efficacy of oral squamous cell carcinoma (OSCC). First, 60 cases of OSCC patients, 60 cases of patients with non-OSCC malignant tumors, and 60 cases of patients with healthy physical condition were collected as the control group in the People's Hospital of Xinjiang Uygur Autonomous Region from January 2015 to January 2018. Each experimental subject were draw 2 mL of fasting peripheral blood, and the tumor markers of SCC-Ag, CYFRA21-1, CEA, CA125, and NSE concentration were detected in the blood respectively. The results showed that the levels of the 5 of serum tumor markers of OSCC patients were different with those of the non-OSCC malignant tumor group. Compared with the control group, there was a significant difference (P<0.05). And the results showed that the sensitivity, specificity, accuracy, and positive predictive values of CEA, CA125, SCC-Ag, CYFRA21-1, and NSE were significantly improved after combined detection. Therefore, the combined detection of the 5 tumor markers can be used for the early diagnosis of OSCC.


Keywords


tumor markers; early screening; oral squamous cell carcinoma

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References


LIU P,DUOLIKUN·WUFUER,CAI ZG,et al. Expression of serum squamous cell carcinoma antigen in Uygur oral squamous cell carcinoma patients[J]. J Int Stomatol,2016,43( 6) : 645 - 650.

Taber, Jennifer & Leyva, Bryan & Persoskie, Alexander. (2014). Why do People Avoid Medical Care? A Qualitative Study Using National Data. Journal of General Internal Medicine. 30. 10.1007/s11606-014-3089-1.

ZHANG L,XUE YF,JI Y,et al. Clinical significance of serum tumor markers and HER2 expression in gastric cancer[J]. J Prac Oncol,2019,34( 1) : 61 - 65.

ZHAO J,LI XJ,YU HD,et al. Evaluation of the combined use of serum tumor markers in the diagnosis of lung cancer in four lung cancers[J]. Genomics and Applied Biology,2018,37( 2) : 661 - 666.

Usher-Smith JA, Sharp SJ, Griffin SJ. The spectrum effect in tests for risk prediction, screening, and diagnosis. BMJ. 2016;353:i3139. Published 2016 Jun 22. doi:10.1136/bmj.i3139

Zheng, Shiya & Zixue, Yang & Chen, Yanping & Dan, Wu & Zhou, Shoubing & Li, Lulu & Zhang, Xiu & Xiaoxiao, Jin & Liu, Zhen & Wang, Cailian. (2016). Simultaneous and combined detection of multiple tumor markers for cancer screening in human serum by upgraded photonic crystal-encoded suspension array. RSC Adv.. 6. 10.1039/C6RA18973C.

CHEN J,WU HK,LI C,et al. Relationship between serum tumor markers and expression of apoptosis - regulated genes in tumor tis- sues in patients with primary liver cancer[J]. International Journal of Laboratory Medicine,2016,37( 3) : 305 - 307.

ZHANG L,XIE WW,XU ZQ,et al. The application value of serum tumor marker detection in the diagnosis of liver cancer[J]. Interna- tional Journal of Laboratory Medicine,2017,38( 21) : 3044 - 3045.

LU RQ,CHEN MM,GUO L. Application of combined detection and scoring model of tumor markers in tumor diagnosis and treatment[J]. Chinese Journal of Laboratory Medicine,2018,41( 3) : 180 - 184.

YANG WL,YANG RP,LUO YS,et al. Application of combined de- tection of seven tumor markers in clinical diagnosis of gastric cancer [J]. Journal of Practical Cancer,2018,33( 6) : 887 - 891.

Zheng J,Sun LC,Yuan WM,et al. Clinical value of Naa10p and CEA levels in saliva and serum for diagnosis of oral squamous cell carcinoma[J]. Journal of Pathology & Medicine,2018,47( 9) : 830-835.

Nakamura H,Nishimura T. History,molecular features,and clinical importance of conventional serum biomarkers in lung cancer[J].Surgery Today,2017,47( 9) : 1037 - 1059.

QIAN Z,HU Y,ZHENG H,et al. Clinical analysis of 22 cases of pulmonary large cell neuroendocrine carcinoma[J]. Journal of Chinese Lung Cancer,2016,19( 2) : 82 - 87.

Fu WY,Chen DL,Bian H,et al. The diagnostic value of serum CYFRA21 - 1,CA199 and SCC in the diagnosis of esophageal cancer[J]. Chongqing Medicine,2017,46( 12) : 1672 - 1674.

WANG ZS. Detection and clinical significance of serum SCC - Ag in patients with esophageal cancer[J]. International Journal of La- boratory Medicine,2015,35( 24) : 3643 - 3644.

Mallick R,Patnaik SK,Wani S,et al. A systematic review of e- sophageal microRNA markers diagnosis and monitoring of Barrett's esophagus[J]. Dig Dig Sci,2016,61( 4) : 1039 - 1050.

Zhang L,Liu D,Li L,et al. The important role of circulating Cyfra 21 - 1 in metastasis diagnosis and prognostic value compared with carcinoembryonic antigen and neuron - specific enolase in lung cancer patients[J]. BMC Cancer,2017( 17) : 96.

HUANG F,XUE L,SONG LL,et al. Diagnostic value of combined detection of pleural effusion and serum CEA,CA125,CYFRA21 - 1,NSE and Pro - GRP in lung cancer[J]. Modern Oncology, 2018,26( 13) : 2054 - 2058.

SHANG L,ZHANG X,CHEN Y,et al. Hippo / YAP signaling reg-ulatory protein ACAN as a novel tumor marker for hepatocellular carcinoma[J]. Laboratory Medicine,2019,34( 1) : 60 - 66.

Li H,Gatsonis C. Sample size estimation for time - dependent re- ceiver operating characteristic[J]. Statistics in Medicine,2014,33 (6):958-970.

ZHAI R,CHENG YZ,SHEN ZJ. The value of combined detection of four serum tumor markers in the diagnosis of lung cancer[J]. Shandong Medicine,2018,58( 1) : 78 - 80.

Rong Rong, Cheng Yizhuang, Shen Zuojun. The value of combined detection of four serum tumor markers in the diagnosis of lung cancer [J]. Shandong Medicine,2018,58(1):78-80.




DOI: http://dx.doi.org/10.30564/amor.v5i4.248

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