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Sensitive Detection of Multiple Tumor Markers for Early Tumor Diagnosis

Hai E Lu (Department of Anesthesia, Children’s Hospital of Fudan University, Shanghai, China)
HaoHong Li (Department of Anesthesia, Anhui Provincial Children’s Hospital, Hefei, Anhui, China)
XinJing Luo (Department of Anesthesia, Children’s Hospital of Fudan University, Shanghai, China;Department of Anesthesia, Anhui Provincial Children’s Hospital, Hefei, Anhui, China)


Tumor markers have a wide clinical applications for early tumor screening and diagnosis. In the study, the combined detection of serum tumor markers (SCC-Ag, CYFRA21-1, CEA, CA125, NSE) was used to explore the correlation and diagnostic efficacy of oral squamous cell carcinoma (OSCC). First, 60 cases of OSCC patients, 60 cases of patients with non-OSCC malignant tumors, and 60 cases of patients with healthy physical condition were collected as the control group in the People's Hospital of Xinjiang Uygur Autonomous Region from January 2015 to January 2018. Each experimental subject were draw 2 mL of fasting peripheral blood, and the tumor markers of SCC-Ag, CYFRA21-1, CEA, CA125, and NSE concentration were detected in the blood respectively. The results showed that the levels of the 5 of serum tumor markers of OSCC patients were different with those of the non-OSCC malignant tumor group. Compared with the control group, there was a significant difference (P<0.05). And the results showed that the sensitivity, specificity, accuracy, and positive predictive values of CEA, CA125, SCC-Ag, CYFRA21-1, and NSE were significantly improved after combined detection. Therefore, the combined detection of the 5 tumor markers can be used for the early diagnosis of OSCC.


Tumor markers; Early screening; Oral squamous cell carcinoma

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