Fe3O4-based Nanoparticles for pH-responsive Dual-modality Imaging and Photothermal Therapy

Jiang Gu, Li Fu, Qianz Dong

Abstract


The study designed a polyacrylic acid (PAA) modified Fe3O4@MnO2 nanoparticles (Fe3O4@MnO2@PAA) for T1/T2 dual-mode imaging. In addition, this nano-drug has pH response and anti-tumor photothermal therapy. First, using Fe3O4 as the core can significantly reduce the signal of Fe3O4@MnO2@PAA nanoparticles. MnO2 nanoshells can be decomposed into paramagnetic Mn2+ under the acidic environment in the tumor, which enhanced the T1 signal. The pH-responsive T1/T2 dual-mode magnetic resonance imaging (MRI) contrast agent had good sensitivity and specificity, providing more comprehensive and detailed information for tumor diagnosis. In addition, Fe3O4@MnO2@PAA nanoparticles showed excellent absorption capacity in the near-infrared region (NIR), which could be used as a good photothermal conversion material to mediate photothermal treatment of tumors. Therefore, the pH-responsive dual-mode MRI nanoparticle-mediated photothermal therapy showed good application potential in tumor treatment and diagnosis.


Keywords


magnetic resonance imaging; diagnostic and therapeutic agents; dual-mode imaging; photothermal therapy

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DOI: http://dx.doi.org/10.30564/amor.v5i4.249

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