Open Journal Systems

Preparation of Graphene Nanocomposite with Targeting Function and Its Photothermal / Photodynamic Combined Therapy

Soo Kyung An (Department of Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul 07441, Republic of Korea)
Ji Wong Hwong (Department of Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul 07441, Republic of Korea)


The study developed a mild method to prepare partially reduced graphene oxide (pRGO). Through the non-covalent interaction of pRGO with nucleic acid aptamers AS1411 and indocytinine green (ICG), photothermal and photosensitive nanocomposites pRGO-AS1411-ICG (pRAI) were constructed. The complex structure and morphological characteristics of pRGO and pRAI were used by fourier transform infrared spectroscopy (FTIR), raman spectroscopy (Raman), X-ray photoelectron spectroscopy (XPS), ultraviolet-visible spectroscopy (Uv-vis), and transmission electron microscope (TEM). And the effect of EDS phototherapeutic back heat therapy on tumor cells was carried out in cell experiments. The results showed that pRAI with targeting of AS1411 can effectively kill tumor cells through the dual effects of photothermal therapy (PTT) and photodynamic therapy (PDT). 


Photothermal therapy; Photodynamic therapy; Reduced graphene oxide

Full Text:



Lucky S. S., Soo K. C., Zhang Y. Chem. Rev., 2015, 115:1990-2042.

Cai Y., Liang P. P., Tang Q. Y., Yang X. Y., Si W. L., Huang W., Zhang Q., Dong X. C. ACS Nano, 2017, 11: 1054-1063.

Yang K., Wan J., Zhang S., Tian B., Zhang Y., Liu Z.Biomaterials, 2012, 33: 2206-2214.

Wang Y. H., Deng H. H., Liu Y. H., Shi X. Q., Liu A. L.,Peng H. P., Hong G. L., Chen W. Biosensors and Bioelectronics, 2016, 80: 140-145.

Akiyama Y., Mori T., Katayama Y., Niidome T. J. Control Release, 2009, 139: 81-84.

Chen R., Wang X, Yao X. K., Zheng X. C., Wang J., Jiang X.Q. Biomaterials, 2013, 34: 8314-8322.

Shiao Y. S., Chiu H. H., Wu P. H., Huang Y. F. ACS Appl.Mater. Interfaces, 2014, 6: 21832-21841.

Gonz. Lez Delgado José A., Kennedy P. J., Ferreira M.,ToméJoao P. C., Sarmento B. J. Med. Chem., 2016, 59:4428-4442.

Barth B. M., Altinoglu E. I., Shanmugavelandy S. S., Kaiser J. M., Crespo⁃Gonzalez D., DiVittore N. A., McGovern C., Goff T. M., Keasey N. R., Adair J. H., Loughran T.P. Jr., Claxton D. F., Kester M. ACS Nano, 2011, 5: 5325-5337.

Yoon H. K., Ray A., Lee Y. E., Kim G., Wang X., Kopelman R. J. Mater. Chem., 2013, 1: 5611-5619.

De la Zerda A., Zavaleta C., Keren S., Vaithilingam S.,Bodapati S., Liu Z., Levi J., Smith B. R., Ma T. J., Oralkan O., Cheng Z., Chen X., Dai H., Khuri Yakub B. T., Gambhir S. S. Nat. Nanotechnol.,2008, 3: 557-562.

Huang Y. F., Chang H. T., Tan W., Anal. Chem., 2008, 80:567-572.

Tang Z., Zhu Z., Mallikaratchy P., Yang R., Sefah K., Tan W. Chem. Asian J., 2010, 5: 783-786.

Shieh Y. A., Yang S. J., Wei M. F., Shieh M. J. ACS Nano,2010, 4: 1433-1442.

Liu J. B., Li Y. L., Li Y. M., Li J. H., Deng Z. X. J. Mater Chem., 2010, 20: 900-906.

Lin Z. Y., Yao Y. G., Li Z., Liu Y., Li Z., Wong C. P. J.Phys. Chem. C, 2010, 114: 14819-14825.

Zhang W., Zhang Y. X., Tian Y., Yang Z. Y., Xiao Q. Q.,Guo X., Jing L., Zhao Y. F., Yan Y. M., Feng J. S., Sun K. N.ACS Appl. Mater. Interfaces, 2014, 6: 2248-2254.

Stathi P., Gournis D., Deligiannakis Y., Rudolf P. Langmuir, 2015, 31: 10508-10516.

Padilha M., Siqueira E, Jesus M., Ceragiol H., Batista Â., Nyúl Tóth Á, Molnár J., Wilhelm I., Maróstica M. Jr.,Krizbai I. Cruz Höfling M. Mol. Pharmaceutics, 2016, 13:3913-3924.

Zhang Y. T., Liu S., Li Y., Deng D. M., Si X. J., Ding Y. P.,He H. B., Luo L. Q., Wang Z. X. Biosensors and Bioelectronics, 2015, 66: 308-315

Ambros A., Chua C. K., Bonanni A., Pumera M. Chem.Mater., 2012, 24: 2292-2298.

Lepock J. R. Int. J. Hyperthermia, 2003, 19: 252-266.

Xu Y. X., Bai H., Lu G. W., Li C., Shi G. Q. J. Am. Chem.Soc., 2008, 130: 5856-5857.

Xu Y. X., Zhao L., Bai H., Hong W. J., Li C., Shi G. Q. J.Am. Chem. Soc., 2009, 19(38): 7030-7035.



  • There are currently no refbacks.

Copyright (c) 2020 Soo Kyung An, Ji Wong Hwong

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.