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Preparation of Graphene Nanocomposite with Targeting Function and Its Photothermal / Photodynamic Combined Therapy

Soo Kyung An (Department of Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul 07441, Republic of Korea)
Ji Wong Hwong (Department of Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul 07441, Republic of Korea)

Abstract


The study developed a mild method to prepare partially reduced graphene oxide (pRGO). Through the non-covalent interaction of pRGO with nucleic acid aptamers AS1411 and indocytinine green (ICG), photothermal and photosensitive nanocomposites pRGO-AS1411-ICG (pRAI) were constructed. The complex structure and morphological characteristics of pRGO and pRAI were used by fourier transform infrared spectroscopy (FTIR), raman spectroscopy (Raman), X-ray photoelectron spectroscopy (XPS), ultraviolet-visible spectroscopy (Uv-vis), and transmission electron microscope (TEM). And the effect of EDS phototherapeutic back heat therapy on tumor cells was carried out in cell experiments. The results showed that pRAI with targeting of AS1411 can effectively kill tumor cells through the dual effects of photothermal therapy (PTT) and photodynamic therapy (PDT). 


Keywords


Photothermal therapy; Photodynamic therapy; Reduced graphene oxide

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DOI: http://dx.doi.org/10.30564/amor.v5i4.250

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