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Study on the Correlation between the Detection of Tumor Markers in Abdominal Effusion and Chemotherapy Sensitivity

Martin Gummert (Department of Community and Family Medicine, AIIMS, Bhubaneswar, Odisha, India)
Namshin Kim (Department of Community and Family Medicine, AIIMS, Bhubaneswar, Odisha, India)

Abstract


Since most patients with ovarian cancer are in the advanced stage when they are prone to recurrence, it is difficult to detect and treat ovarian cancer. There are tumor serum markers in the ascites. Therefore, the study explored the correlation between the serum marker levels of the ascites and chemotherapy sensitivity in patients with ovarian malignant tumors. First, 50 patients with nested cancer were selected as research subjects and received treatment, and then immediately 200 mg carboplatin + 100 mL normal saline was placed in the abdominal cavity of all patients, which was equivalent to an intraperitoneal chemotherapy. Carboplatin + docetaxel combined with intravenous chemotherapy was started 3 weeks after surgery, and chemotherapy was given every 3 weeks for a total of 5 to 6 courses. The serum levels of CA125, CA199, CEA and AFP in peripheral blood and peripheral blood were determined by ELISA. The results showed that the levels of CA125, CA199, CEA and AFP in serum and ascites after chemotherapy were lower than before chemotherapy (P<0.05). The short-term effective rate of 50 ovarian cancer patients (8 CR, 28 PR, 12 SD, 2 PD) was 72.00 %. Therefore, patients with ovarian malignant tumors had a good short-term curative effect after chemotherapy, which can reduce the ascites and serum levels of CA125, CA199, CEA, AFP for clinical reference value.


Keywords


Chemotherapy sensitivity; Tumor markers; Malignant ovarian cancer

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DOI: http://dx.doi.org/10.30564/amor.v5i4.251

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