Clinical Effect and Tolerance Analysis of Photodynamic / Electroion in the Treatment of Skin Cancer and Precancerous Lesions

Nicole H. Dalal, Krisztina Bogos

Abstract


The study was dedicated to explore the clinical efficacy and tolerability of photodynamic /electroion therapy of skin cancer and precancerous lesions. Firstly, a total of 60 patients with skin cancer and precancerous lesions, who were admitted to the Dermatology Department of the Fifth Affiliated Hospital of Zhengzhou University from November 2013 to November 2016, were selected and divided into observation group and control group according to the random number table, with 30 patients in each group. Observation group adopted the photodynamic/ electroion therapy, and control group adopted photodynamic therapy (PDT). Two groups of patients were last follow-up to December 2018, and loss of follow-up and death were taken as the end point events of follow-up. The frequency of treatment, clinical efficacy and severity of adverse reactions of the two groups were calculated, and Kaplan-Meier curves were plotted to compare the progression free survival (PFS) of the two groups. The results showed that the number of treatment times per capita in the observation group was 3.6 ± 1.1 times, which was lower than that of in the control group (4.1 ± 1.1 times), but the difference was not statistically significant (t = 1.760, P = 0.083). The total effective rate in the observation group (100. 00 %) was higher than that of in the control group (80. 00 %), and the difference was significant (P < 0.05). In addition, during the treatment, both groups had adverse reactions such as burning, pain, redness, swelling and exudation of different degrees, but there was no significant difference in the severity score of adverse reactions (P >, 0.05). There was no statistically significant difference in the follow-up time and PFS between the two groups (P > 0.05), but the recurrence rate of the observation group was significantly lower than that of the control group (P < 0. 05). Therefore, the clinical efficacy of photodynamic /electroion treatment in patients with skin cancer and precancerous lesions was superior to that of PDT alone, which increased the risk of tolerance. So, it is worthy of clinical promotion.


Keywords


Photodynamic therapy; Electroion therapy; Skin cancer. Precancerous lesions

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DOI: http://dx.doi.org/10.30564/amor.v5i5.252

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