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Clinical Efficacy and Adverse Reactions of Photodynamic Therapy in the Treatment of Malignant Skin Tumors and Precancerous Skin Diseases

Andrew L. Mason (Department of Genetics, University of North Carolina, Chapel Hill, NC)
Chadia Chourabi (Alliance Protocol Operations Office, University of Chicago, Chicago, IL)


The purpose of the study was to investigate the efficacy and safety of photodynamic therapy in the treatment of malignant skin tumors and precancerous skin diseases. First of all, 100 patients with malignant skin tumor and pre-cancer skin disease admitted to our hospital from January 20, 2018 to September 18, 2018 were selected, and all of them adopted photodynamic therapy. The 100 patients included 40 cases of basal cell carcinoma, 14 cases of squamous cell carcinoma, 7 cases of proliferative erythema, 9 cases of Bowen's disease and 39 cases of solar keratosis. Among the 100 patients, 77 cases had excellent curative effect, 18 cases had good effect and 5 cases had poor effect, and the overall effective rate was 95% (95/100). After 6 months of follow-up, 5 cases of basal cell carcinoma, 2 cases of squamous cell carcinoma, 0 cases of proliferative erythra, 1 case of Bowen's disease and 3 cases of solar keratosis recurred, with an overall recurrence rate of 14%(14/100). The adverse reactions of pruritus were 90%(90/100), 81%(81/100), 90%(90/100) and 3%(3/100). Therefore, the application of photodynamic therapy in the treatment of malignant skin tumors and precancerous skin diseases is not only effective, but also safe and not easy to relapse.


Malignant skin tumor; Precancerous skin disease; Photodynamic therapy; Adverse reactions

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Copyright (c) 2020 Andrew L. Mason, Chadia Chourabi

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