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Clinical Effect of Photodynamic Therapy Combined Cryotherapy on Nonmelanoma Skin Cancer

Stephen A. Cannistra (Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD 20892, USA)
Naveed Saleh (Department of Business Analytics, Tunis Business School, El Mourouj, Tunisia)


The purpose of this study was to investigate the clinical efficacy of photodynamic combined freezing in patients with non-melanoma skin cancer (NMSC). First, according to the treatment regimen, 96 patients with NMSC were divided into study group (n=50) and control group (n=46). The control group was treated with 5-amino-ketovalic acid photodynamic therapy (ALA-PDT), while the study group was treated with ala-PDT combined with cryotherapy. Visual analogue scale (VAS) scores, visual satisfaction, clinical efficacy, adverse reactions, and progression-free survival were compared between the two groups. The results showed that VAS score in the study group was slightly higher than that in the control group, but the difference was not statistically significant (P>0.05). The appearance satisfaction and total effective rate of patients in the study group were higher than those in the control group, and the difference was statistically significant (P< 0.05). The total incidence of adverse reactions in the study group was slightly higher than that in the control group, but the difference was not statistically significant (P>0.05). 3 years progression-free survival time and 3 years progression-free survival rate were compared between the two groups, and the difference was not statistically significant (P>0.05). Therefore, the combination of PDT and cryotherapy for non-melanoma skin cancer has a good clinical effect, which is conducive to the recovery of skin lesions, high patient satisfaction, fewer adverse reactions, and longer progression-free survival. In addition, the combined therapy can provide a new treatment idea for non-melanoma skin cancer patients who are not suitable for surgical treatment.


Photodynamic therapy; 5-amino-ketovalic acid; Recovery; Non-melanoma skin cancer; Clinical efficacy; Adverse reactions

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