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Clinical Study of Aminolevulinic Acid-mediated Acid Photodynamic Therapy Combined with Surgical Therapy of Skin Malignant Tumor

Min Sun Bae (Department of Radiation Medicine, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, 450 Lakeville Road, Lake Success, NY 11040, USA)
Elizabeth J. Sutton (ALX Oncology, Burlingame, CA, USA)

Abstract


The purpose of the study was to analyze the effects of aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) combined with surgery and its prognostic implications. Firstly, 70 cases of skin malignant tumors admitted to the dermatology department of our hospital from January 2017 to December 2018 were selected and divided into observation group and control group according to the random number table, with 35 patients in each group. Observation group adopted the ALA-PDT combined with surgery therapy, and control group adopted surgery therapy. Two groups of patients were last follow-up to December 2019. The results showed that the total effective rate of clinical treatment in the observation group was significantly higher than that in the control group (P<0.05), indicating that based on the basis of conventional surgical treatment, combined use of ALA-PDT can effectively improve the clinical therapeutic effect and better promote the patient's health recovery. Therefore, combined with surgical treatment, ALA-PDT can improve the clinical efficacy of skin malignant tumors with fewer adverse reactions, high safety, low recurrence rate and ideal long-term prognosis. 


Keywords


Photodynamic therapy; Surgery therapy; Skin malignant tumor

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DOI: http://dx.doi.org/10.30564/amor.v5i6.258

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Copyright (c) 2020 Min Sun Bae, Elizabeth J. Sutton

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