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Clinical Study of Aminolevulinic Acid-mediated Acid Photodynamic Therapy Combined with Surgical Therapy of Skin Malignant Tumor

Min Sun Bae (Department of Radiation Medicine, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, 450 Lakeville Road, Lake Success, NY 11040, USA)
Elizabeth J. Sutton (ALX Oncology, Burlingame, CA, USA)


The purpose of the study was to analyze the effects of aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) combined with surgery and its prognostic implications. Firstly, 70 cases of skin malignant tumors admitted to the dermatology department of our hospital from January 2017 to December 2018 were selected and divided into observation group and control group according to the random number table, with 35 patients in each group. Observation group adopted the ALA-PDT combined with surgery therapy, and control group adopted surgery therapy. Two groups of patients were last follow-up to December 2019. The results showed that the total effective rate of clinical treatment in the observation group was significantly higher than that in the control group (P<0.05), indicating that based on the basis of conventional surgical treatment, combined use of ALA-PDT can effectively improve the clinical therapeutic effect and better promote the patient's health recovery. Therefore, combined with surgical treatment, ALA-PDT can improve the clinical efficacy of skin malignant tumors with fewer adverse reactions, high safety, low recurrence rate and ideal long-term prognosis. 


Photodynamic therapy; Surgery therapy; Skin malignant tumor

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Serpik VG, Kulikov A. PUK7-budget impact evaluation of treat- ment with a low protein diet and ketoanalogues of essential aminoacids for predialysis patients in Russian Federation [J]. Value Health, 2014, 17(7): A467.

Wu J X. Clinical prognosis of skin tumors treated by surgery alone and combined with aminoketovalic acid photodynamic therapy [J]. Zhejiang Trauma Surgery Department, 2016, 21(5): 971-973.

Deng L L. Clinical prognosis of skin tumors treated by surgery alone and combined with 5-amino-ketovalic acid photodynamic therapy [J/CD]. Journal of Integrated Chinese and Western Medicine, 2018, 21(27):171.

Scott KR, Adesioye S, Ayuk PB, et al. Synthesis and evaluation of amino analogues of valproic acid[J]. Pharmac Res, 2016, 11 (4): 571-574.

Zheng Y, Dong D K, Zhai J X, et al. Clinical analysis of 13 cases of solar keratosis treated by surgery combined with 5-amino-ketovalic acid photodynamic therapy [J]. Bulletin of Dermatology, 2012, 10(6):340-341.

Liu F, Liu G, Guo H X, et al. Photodynamic therapy with 5-amino-ketovalic acid for the treatment of solar keratosis [J]. Chinese Journal of Integrated Traditional and Western Medicine dermatology, 2015, 15(2):32-34.

Huang Y Z. Clinical efficacy observation of 5-amino-ketovalic acid photodynamic therapy in the treatment of skin tumors [J]. Skin and Venereal Diseases, 2016, 168(1):140-141.

Fan J Y, Li J, Wang S L, et al. Therapeutic effect of 5-amino-ketovalerate photodynamic therapy, surgery and imiquimide in the treatment of basal cell carcinoma of the skin [J]. Journal of clinical rational drug use, 2016,9 (4):74-75.



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