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Analysis of Clinical Effect of Concurrent Chemo/radiotherapy in the Treatment of Advanced Cervical Cancer

Rebaz Mohammed (National Physical Laboratory, United Kingdom)
Christopher Halpin (University of Surrey, United Kingdom)

Abstract


The study aimed to analyze the efficacy and adverse effects of concurrent chemo/radiotherapy in the treatment of advanced cervical cancer, and the efficacy and safety of concurrent chemo/radiotherapy were evaluated to standardize the treatment. First of all, retrospective analysis was carried out, and 30 cases of advanced cervical cancer treated in hospitals from 2013 to 2018 were included in the study. 30 cases of concurrent chemo/radiotherapy were included in the synchronous group, and 30 cases of radical radiotherapy alone were included in the radiotherapy group. The results showed that the CR rate and remission rate in the synchronous group were 43.3% and 93.3%, which were higher than those in the radiotherapy group (26.7% and 80.0%). The 3-year survival rate of the synchronous group was 80.0%, which was higher than that of the radiotherapy group, with a statistically significant difference (P<0.05). There was no significant difference in 3-year all-cause mortality, 5-year survival and 5-year all-cause mortality between the two groups. The tumor-free survival time in the synchronous group was (24.4±8.2) months, which was higher than that in the radiotherapy group (17.0±8.5) months, and the difference was statistically significant (P<0.05). Therefore, compared with radiotherapy alone, concurrent chemo/ radiotherapy in the treatment of advanced cervical cancer can improve the 3-year survival rate and prolong the tumor-free survival time. However, it did not increase 5-year survival rate, and bone marrow suppression and gastrointestinal reactions were increased. 


Keywords


Cervical cancer; Concurrent chemo/radiotherapy; Radical radiotherapy alone; Survival rate

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References


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DOI: http://dx.doi.org/10.30564/amor.v5i6.259

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Copyright (c) 2020 Rebaz Mohammed, Christopher Halpin

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