A Controlled Study on the Effect of Preoperative Nutritional Assessment and Intervention on the Clinical Efficacy of Patients with Esophageal Cancer

Jaeho Cho, Dr Sc Hum


The purpose of this study was to analyze the effect of preoperative nutritional assessment and intervention on the clinical efficacy of patients with esophageal cancer. First, 110 patients with esophageal cancer admitted to our hospital from December 2014 to December 2016 were selected, including 78 males and 27 female were randomly selected as the observation group and control group. In the observation group, 26 cases received nutritional support, 22 cases did not receive nutritional support, 15 cases in the control group, 47 cases did not receive nutritional support. The non-protein calories were no less than 41.8kj •kg-1• d-1. Albumin (PAB), transferrin (TRF) and albumin (ALB) were tested before, 1 and 5 days after surgery. IgA, IgG and IgM were detected by immunosuspension analyzer. Flow cytometry was used to detect CD3 and CD4. The incidence of postoperative complications (incision infection, pulmonary infection, anastomotic fistula, chylothorax, bleeding, esophagotracheal fistula, cardiovascular complications, and digestive tract diseases) was observed. The results showed that 48 patients (43.64%) in the observation group had nutritional risk (≥3 points), while 62 patients (56.36%) in the control group had no nutritional risk (<3 points). There were statistically significant differences between the observation group and the control group in gender, degree of differentiation, etc. (P<0.05), but no significant differences in age, complications, tumor size, metastasis, lymph node metastasis, etc. (P>0.05) postoperative indicators showed that all indicators continued to decline. The level of immune factors in the nutrition support group was higher than 1 day before surgery and close to the preoperative level. This indicated that effective preoperative nutritional support for esophageal cancer patients with nutritional risk can inhibit the decomposition of immunoglobulin, which is conducive to the recovery of postoperative immune function and improve the tolerance of the body to comprehensive tumor treatment. At the same time, the incidence of postoperative complications in the nutritional support group was significantly lower than that in the non-nutritional support group, indicating that active preoperative nutritional support intervention can reduce the occurrence of postoperative complications and improve the prognosis of patients.


Esophageal cancer; Nutritional support; Complications

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DOI: http://dx.doi.org/10.30564/amor.v5i6.261


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