Open Journal Systems

Diagnostic Value of Quantitative Parameters of DCE-MRI in Endometrial Carcinoma and Its Correlation with Clinicopathological Factors

Xinyi Fang (Central Hospital of Fengcheng City,Dandong City,Liaoning Province,China)

Abstract


In the study, 108 patients with endometrial cancer were selected as the observation group, and 105 patients with benign endometrial lesions were selected as the control group. After DCE-MRI examination, it was found that the volume transfer constant (Ktrans), rate constant (Ke) and extracellular space volume ratio (Ve) in the observation group were higher than those in the control group (P < 0.05). The area under curve (AUC) of combined Ktrans, Ke and Ve values in the diagnosis of endometrial cancer was 0.841. The values of Ktrans, Ke and Ve were positively correlated with the clinical stage and the degree of muscular invasion, but negatively correlated with the degree of differentiation (P < 0.05). The results of the study suggested that DCE-MRI quantitative parameters have a certain value in the differential diagnosis of endometrial cancer, which helped to further distinguish the degree of muscular invasion, clinical stage, and differentiation of endometrial cancer patients. 


Keywords


dynamic contrast enhanced magnetic resonance imaging; volume transfer constant rate constant; extravascular extra-cellular space volume ratio; endometrial cancer; clinicopathological factors

Full Text:

PDF

References


Gynecological Oncology Committee of Chinese Anti-Cancer Association. Journal of Clinical Gynecology and Obstetrics, 2018,34 (8) : 880-886.

Yang Y, Zhao LJ, Wang ZQ, et al. Research progress in the classification of endometrial carcinoma [J]. Chinese Journal of Obstetrics and Gynecology, 2016,51 (6):474-476..

Colombo N,Creutzberg C,Amant F,et al.ESMO-ESGO- ESTRO consensus conference on endometrial cancer: diagno- sis,treatment and follow-up [J]. International Journal of Gynecological Cancer, 2016, 26(1):2-30.

Wang XD, Wang LL. The clinical value of hysteroscopy and diagnostic curetection in the diagnosis of endometrial carcinoma and precancerous lesions [J]. Journal of Preventive Medicine of PLA, 2019,37 (6):95-96.

Nam J G,Kang K M,Choi S H,et al.Comparison betwen the prebolus T1 measurement and the fixed T1 value in dy- namic contrast-enhanced MR imaging for the diferentiation of true progresion from pseudoprogresion in glioblastoma treated with concurent radiation therapy and temozolomide chemotherapy [J]. American Journal of Neuroradiology, 2017, 38(12): 2243-2250.

Lin C Y. Correlation between incoherent motion and dynamic enhancement parameters in endometrial carcinoma [J]. Journal of Radiological Practice, 2019,34 (10):1088-1091.

Le S W,Le T S,Hong D G,et al.Practice guidelines for management of uterine corpus cancer in Korea:a korean society of gynecologic oncology consensus statement[J].Journal of Gynecologic Oncology, 2017, 28(1):e12.

Lu Wanting, Yan Siyou, Hu Zhijian, et al. Endometrial carcinoma: a review [J]. Journal of Applied Obstetrics and Gynecology, 2019, 35 (6) : 459-4 62.

Chen XF, Wang PF, Liu C C, et al. Prognostic factors of 159 patients with endometrial carcinoma of the stage of Fi Go T [J]. Chinese Journal of Cancer Prevention and Treatment, 2019, 26 (6) : 416-420.

Lang N,Su M Y,Xing X,et al.Morphological and dynamic contrast enhanced MR imaging features for the diferentiation of chordoma and giant cel tumors in the axial skeleton [J]. Journal of Magnetic Resonance Imaging, 2017, 45 (4 ): 1068-1075.

Kim H S,Yoon Y C,Kwon S,et al.Dynamic contrast-en- hanced MR imaging parameters in bone metastases from non- smal cel lung cancer:comparison betwen lesions with and lesions without epidermal growth factor receptor mutation in primary lung cancer[J].Radiology,2017,284(3):815-823.

Bourgioti C,Chatoupis K,Panourgias E,et al.Endometrial vs.cervical cancer:development and pilot testing of a mag- netic resonance imaging (MRI)scoring system for predicting tumor origin of uterine carcinomas of indeterminate histology[J]. Abdominal Imaging, 2015, 40(7):2529-2540.

Zhou Yiming, Chen Hong, Xu Zhujin, et al. Comparison of dynamic contrast-enhanced MRI quantitative and semi-quantitative hemodynamic parameters for the differentiation of benign and malignant breast lesions [J]. Chinese Journal of Medical Imaging, 2019, 35(4):488-492.

Zhou Xiaojun, Wen Caiyun, Wang Chunyuan, et al. Comparison of dynamic contrast-enhanced magnetic resonance imaging with diffusion weighted imaging in breast cancer patients [J]. Chinese Journal of Pharmacology and Clinics, 2019,19 (23):4040-4043.

Zhu Q. Study of normal uterus and value of DWI and DCE-MRI in diagnosis of early endometrial cancer [D]. Wuhu: Wannan Medical College, 2019.

Zhang P, Xiao H, Wang L. Effect of DCE-MrI combined with DWI on preoperative muscle infiltration and clinical stage diagnosis accuracy in patients with endometrial carcinoma [J]. Modern Medical Imaging, 2018, 27(5):14-15.

Fasmer K E,Bjrnerud A,Ytre-Hauge S,et al. Preoperative quantitative dynamic contrast-enhanced MRI and difusion-weighted imaging predict aggresive disease in endometrial cancer[J].Acta Radiologica, 2018, 59(8): 1010-1017.



DOI: http://dx.doi.org/10.30564/amor.v6i2.269

Refbacks

  • There are currently no refbacks.


Copyright (c) 2020 Xinyi Fang

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.