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Non-coding RNAs: New therapeutic targets and opportunities for hepatocellular carcinoma

Yu Cuiyun ()
Qian Ning ()
Zhi-Ping Li ()
Wen Huang ()
Jia Yu ()
Xiao-Yan Yang ()
Xiao-Yong Lei ()


Non-coding RNAs (ncRNA) are RNA molecules without protein coding functions owing to the lack of an open reading frame (ORF). Based on the length, ncRNAs can be divided into long and short ncRNAs; short ncRNAs include miRNAs and piRNAs. Hepatocellular carcinoma (HCC) is among the most frequent forms of cancer worldwide and its incidence is increasing rapidly. Studies have found that ncRNAs are likely to play a crucial role in a variety of biological processes including the pathogenesis and progression of HCC. In this review, we summarized the regulation mechanism and biological functions of ncRNAs in HCC with respect to its application in HCC diagnosis, therapy and prognosis.


hepatocellular carcinoma; ncRNA; miRNA; lncRNA; piRNA

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