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Efficacy of Huangqi Taohong Decoction Combined with TP Chemotherapy on Advanced Cervical Cancer and Its Influence on PD-L1/PD-1 Pathway, Tumor Markers and Th Cytokines

Y. Ma (Peking University People's Hospital, Beijing, China)

Abstract


Objective. To observe the clinical efficacy of Huangqi Taohong Decoction combined with TP chemotherapy on advanced cervical cancer (CC) and its effect on programmed death molecule1/programmed death molecule-1 ligand pathway, tumor markers and Th cytokines. Methods. A total of 115 patients with advanced CC were randomly divided into two groups, 57 patients in the control group were treated with TP chemotherapy, 21 days as a course, and the treatment lasted for 4 courses. 58 cases in the treatment group were treated with Huangqi Taohong decoction on the basis of control group, and 4 weeks was as a course and the treatment was lasted for 3 courses. The curative effects of the two groups were compared. The changes of PD-1 on CD4+ T cells, PD-L1 on CD14+ monocytes were compared before and after treatment. The changes of tumor markers [carcinoembryonic antigen ( CEA) , sugar chain antigen ( CA199) , carbohydrate antigen ( CA125), squamous cell carcinoma antibody (SCC-A)] were compared, the levels of Th1 cytokines [γ-interferon ( INF-γ) , interleukin-2 ( IL-2)], th2 cytokine [interleukin-4 ( IL-4) , interleukin-6 ( IL-6) ], quality of life score and the incidence of adverse reactions were compared between the two groups before and after treatment. Results. The disease control rate (DCR) was 74.14% ( 43/58) in the treatment group and 63.16% (36 /57) in the control group, and there was no significant difference between the two groups( P > 0. 05). After treatment, PD-1on CD4+ T cells, PD-1 on CD8+ T cells and PD-L1on CD14+ monocytes in the treatment group were lower than those before treatment (P<0.05), and lower than those in the control group (P<0.05). There was no significant difference in PD-1 on CD4+ T cells, PD-1 on CD8+ T cells and PD-L1 on CD14+ monocytes before and after treatment in the control group (P>0.05). After treatment, the levels of serum CEA, CA199, CA125 and SCC-A in the two groups were lower than those before treatment(P<0.05), and the decrease in the treatment group was more significant(P<0.05). After treatment, the serum INF-γ, IL-2, IL-4 and IL-6 levels in the two groups were lower than those before treatment (P<0.05), and the decrease in the treatment group was more significant(P<0.05). After treatment, the CC Quality of Life Assessment Scale (FACT-Cx) showed that physiological status, social/family status, emotional status, functional status, CC specific module score and total score were all higher than those before treatment in this group and after treatment in the control group (P<0.05) . There was no significant difference in physiological status, so-cial/family status, emotional status, functional status, CC specific module score and total score before and after treatment in the control group (P>0.05). The difference in the incidence of adverse reactions between the two groups was statistically significant (P<0.05). And the incidence of adverse reactions in the control group was higher. Conclusion. Huangqi Taohong Decoction combined with TP chemotherapy is effective in the treatment of advanced CC. It can block the expression of PD-1/PD-L1 pathway, reducing the expression levels of tumor markers, Th1 and Th2 cytokines, improving the quality of life and safety.


Keywords


Cervical cancer; Integrated traditional Chinese and Western medicine therapy

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References


Dong Hoon Suh, Miseon Kim, Kyung Hun Lee, et al.. Advances in Gynecologic Canc-ER in 2017 [J]. J Gynecol Oncol, 2018,29 (2) : E31.

Yang Shaoyan, Zhao Weidong. Changes in vaginal microenvironment are associated with cervical cancer

[J]. Shenzhen Journal of Integrated Traditional Chinese and Western Medicine, 2017,27

(6) : 182-185.

HU Lidan, LU Xueying, HU Yuenan, et al. HPV infection in patients with cervical lesions: an epidemiological investigation and risk factors [J]. Chinese Journal of Nosocomiology, 2017,27 (22) : 5212-5215.

Li Haoshan, Wang Junhai, Tian Jun. Effects of paclitaxel combined with carboplatin on immune function and serum SCC-Ag and TSGF levels in patients with advanced cervical cancer [J]. Journal of Applied Cancer, 2018,33

(4) : 556-560.

Genevieve P Hartley, Lyndah Chow, Dylan T am-Mons, et al.. Programmed Cell Death Ligand 1 (PD-L1) Signaling Regulates Macrophage Proliferation and Activation [J]. Cancer Immunol Res, 2018,6 (10) : 1260-1273.

Ren Yongji, Li Donglei. Matrine injection chemotherapy in patients with cervical cancer

Effects of sensitization on quality of life and immune function of patients

[J]. Journal of Modern Integrated Traditional and Western Medicine, 2017,26 (23) : 2535-

5.

Gynaecological Oncology Committee of the Chinese Anti-Cancer Association. Cervical cancer diagnosis and treatment guidelines (4th Edition) [J]. Chinese Journal of Applied Gynecology and Obstetrics, 2018,34 (6) : 613-622.

China Association of Traditional Chinese Medicine. Cancer diagnosis and treatment guide of traditional Chinese medicine [M]. Beijing: China Press of Traditional Chinese Medicine, 2008:147.

ZHOU Lin, MENG Qiong, YANG Zheng, et al. Based on fact-cx (V4. 1) Analysis of factors influencing quality of life in patients with cervical cancer [J]. Chinese Journal of Disease Control, 2017,21 (9) : 926-929,938.

Li Haoran, Wu Xiaohua, Cheng Xi. Advances in Diagnosis and Treatment of Metastatic Cervical Cancer [J]. J Gynecol Oncol, 2016,27 (4) : E43.

Chen Junmao, Xu Ce, Hu Shanshan. The different chemotherapy regimens were locally advanced

[J]. Journal of Applied Cancer, 2017,32 (3) : 464-465,468.

Lalit Kumar, P Harish, Prabhat S Malik, et al.. Chemo-therapy and targeted therapy in the management of cervical cancer [J]. Curr ProBL Cancer, 2018,42 (2) : 120-128.

Ma Xiaoping, Gan Lin, Wan Guiping. Traditional Chinese medicine in prevention of cervical HPV infection Progress in the research of treatment [J]. Sichuan Traditional Chinese Medicine, 2017,35 (6) :215-217.

Zhang Weiwei. Study on the changes of TCM syndromes before and after concurrent chemoradiotherapy for middle and advanced cervical cancer [D]. Nanjing: Nanjing University of Chinese Medicine, 2019.

WANG Zhirong, GONG Pijun, WANG Guixian, et al. Effects of Huangqi Taohong decoction adjuvant chemotherapy on cellular immune function in patients with cervical cancer [J]. Laboratory Medicine & Clinical Practice, 2017,14 (12) : 1759-1761.

XIONG Jiaqing, WU Shiting, LI Kui, et al. Effects of Huangqi Jiedu Decoction on the expression of JAG1 gene and CyclinD1 protein in breast cancer cells [J]. Journal of Hunan University of Chinese Medicine, 2018,38 (2) : 145-149.

WANG Qiushi, SHEN Hong, XU Dan, et al. Effects of Xihuang pill combined with TP neoadjuvant chemotherapy on chemotherapy efficacy, immune function and tumor markers in patients with advanced cervical cancer [J]. Hebei Traditional Chinese Medicine, 2018,40 (6) : 827-

LU Liwei, LAN Guancui, ZHU Xiaohua, et al. Effect of matrine injection on serum tumor markers in patients with cervical cancer after neoadjuvant chemotherapy

[J]. Prevention and Control of Chronic Diseases in China, 2018,26 (6) : 444-

Meng Jianhua. Effects of Shenqi Fuzheng Injection and Sanshenqi Oral Liquid on Cell Immune Function of Patients with Postoperative Radiotherapy for Cervical Cancer [J]. Journal of Integrated Traditional Chinese and Western Medicine, 2017,26 (5) : 477-480.

JI Fei, HE Yan, YANG Li, et al. Expression and prognostic significance of Th1/Th2 cytokines in patients with cervical cancer [J]. Chongqing Medical Science, 2018,47

(33) : 4229-4233.

YIN Linlin, SHU Lisha. Progress in the study of PD-L1/PD-1 pathway in cervical cancer [J]. Journal of Medical Research, 2018,47 (7) : 13-16, 20.



DOI: http://dx.doi.org/10.30564/amor.v6i6.292

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