Open Journal Systems

The Value of Six Serum Tumor Markers in the Diagnosis of Lung Cancer

H. Wang (The Fourth People's Hospital of Shenyang City, Shenyang, China)


Objective. To investigate the diagnostic value of carcinoembryonic antigen (CEA), carbohydrate antigen (CA199), carbohydrate anti- gen 125 (CA125), angiopoietin (Ang-12), Cytokeratin-19-fragment (CYFRA211) and alpha fetoprotein (AFP) for lung cancer. Methods. 85 lung cancer patients (lung cancer group), 90 patients with benign lung disease (benign lung disease group) and 80 people (control group) controls who were admitted to our hospital from January 2016 to April 2019 were selected as the research subjects, the lung cancer group was divided into squamous cell carcinoma group (n=41), adenocarcinoma group (n=29) and small cell carcinoma group (n=15) according to the pathological examination results. The expression of CEA, CA199, CA125, Ang-2, CYFRA211 and AFP were compared among the three groups. Results. The levels of CEA, CA199, CA125, Ang-2, CYFRA211 and AFP in lung cancer group were higher than in benign lung disease group and control group (P<0.05). The level of Ang-2 in small cell carcinoma group was lower than adenocarcinoma group and squamous cell carcinoma group(P<0.05). The level of CYFRA211 in squamous cell carcinoma group was higher than that in adenocarcinoma group and squamous cell carcinoma group(P<0.05). There was significant difference in the indexes of lung cancer patients with different pathological stages (P<0.05). Conclusion. CEA, CA199, CA125, Ang-2, CYFRA211 and AFP have good diagnostic efficacy for lung cancer, which have certain reference value for the diagnosis of lung cancer pathological staging and histological classification, and are worthy of clinical promotion and application.


Carcinoembryonic antigen; Carbohydrate antigen; Angiopoietin; Cytokeratin 19 fragment; Alpha-fetoprotein; Lung cancer

Full Text:



Wang Yan, Jiao Lili. Clinical significance of serum CEA CA199 in the prediction of non-small cell lung cancer [J]. Chinese Journal of Practical Internal Medicine,2013,33(S2):7-8.

Li Shaolei, Ma Yuanyuan, Xiong Ying, et al. Cancer Research [J]. Cancer Research,2018,45(1):24-28.

Liu fang. The value of serum tumor markers combined detection in the diagnosis and treatment of non-small cell lung cancer with brain metastasis [J]. Journal of Applied Cancer,2017,32(4):578-581.

Wang Yuchao, Yang Xiaohong, Wu Chao. Analysis of serum tumor markers CEA, CA199, CA125, CA153 in patients with idiopathic pulmonary fibrosis combined with lung cancer [J]. Shandong Medicine,2013,53(29):78-79.

Yang Lanping, Huang Hansheng, Chen Huihua, et al. Clinical significance of serum CYFRA211, CEA, NSE, CA125 and CA199 levels in patients with non-small cell lung cancer before and after chemotherapy [J]. Journal of Applied Clinical Medicine,2014,18(17):40-43.

Zuo Jianghua, Li Zongliang, Ren Hongtao. Diagnostic value of serum CEA, CA125 and CA199 in the diagnosis of lung cancer [J]. Marker Immunoassay and Clinics,2016,23(6):668-671.

Chen Yangyang, Zhang Jie, Xu Guobin. Clinical significance of serum tumor markers in patients with advanced lung cancer after first-line chemotherapy [J]. Journal of Clinical Laboratory Medicine,2015,33(2):124-129.

Tian Manfu, Han Bo. Diagnostic significance of CA199, CA125, CA153 and CEA in tumor diagnosis [J]. Journal of Clinical and Experimental Medicine,2010,9(7):483-485.

Kang Lianzong, Xiao Jinyu, Wang Xiaoxu. Clinical significance of tumor markers CA153 and CA125 in the diagnosis of lung cancer [J]. Clinical Research & Practice,2019,4(36):127-129.

Gong Hongjuan, Cai Jinhong, Gong Julan.. The value of serum CYFRA21-1, CEA, NSE, CA199, CA125 combined detection in the diagnosis of lung cancer [J]. Guizhou Medicine,2019,43(3):450-453.



  • There are currently no refbacks.

Copyright (c) 2021 H. Wang

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.