Research progress on the safety of cell-assisted lipotransfer in breast repairs after breast conserving therapy

Xingzi Liu, Jing Han


With the development of medical technology, more breast cancer patients have the opportunity of receiving breast conserving therapy. Post-operation breast reconstructions have gained more attention nowadays. As a new and important method of breast reconstruction after breast surgery, cell-assisted lipotransfer is being carried out in some clinical works. This paper briefly reviewed the current research progress of adipose-derived stem cell-assisted lipotransfer and the recurrence of breast cancers.


breast conserving therapy; breast reconstruction; adipose-derived stem cell; cell-assisted lipotransfer

Full Text:



Tian C, Lü Q. Advancement of adipose-derived stem cells assisted autologous lipotransfer in breast repair and reconstruction. Chinese Journal of Reparative and Reconstructive Surgery 2013; 10: 1252–1254.

Wang S, Yao C. Comments on certain issues of breast- conserving surgery in breast cancer. Chinese Journal of Surgery 2009; 7: 494–496.

Fisher B, Redmond C, Legault-Poisson S, Dimitrov NV, Brown AM, Wickerham DL, Wolmark N, Margolese RG, Bowman D, Glass AG, Kardinal CG, Robidoux A, Jochimsen P, Cronin W, Deutsch M, Fisher ER, Myers DB, Hoehn JL. Postoperative chemotherapy and tamoxifen compared with tamoxifen alone in the treatment of positive-node breast cancer patients aged 50 years and older with tumors responsive to tamoxifen: results from the National Surgical Adjuvant Breast and Bowel Project B-16. J Clin Oncol 1990; 8(6): 1005–1018.

Jobsen JJ, van der Palen J, Brinkhuis M, Ong F, Struikmans H. Sequence of radiotherapy and chemotherapy in breast cancer after breast-conserving surgery. Int J Radiat Oncol 2012; 82(5): 811–817. doi: 10.1016/j.ijrobp.2011.11.020.

Ursaru M, Jari I, Negru D, Scripcariu V. Local and distant recurrences – a comparative study on conservative and radical surgery for breast cancer. Chirurgia (Bucur) 2015; 110(1): 38–42.

Pang Z. Evaluation of quality of life and efficacy of breast cancer patients treated with breast-conserving surgery. Chine Pract J Cancer 2014; 3: 324–332.

Lin W, Xie C. Analysis on 34 cases of breast-conserving surgery for early breast cancer. Jilin Med J 2014; 11: 2396–2397.

Yang H. Experience of treatment of breast conserving operation for breast cancer patients in the early stage. Chin Comm Doc 2014; 21: 66–68.

Zai T, Mu T, Gu L. Analysis on clinical efficacy of breast conserving surgery for patients with early breast cancer. Jilin Med J 2015; 9: 1840–1841.

Cowher MS, Grobmyer SR, Lyons J, O’Rourke C, Baynes D, Crowe JP. Conservative axillary surgery in breast cancer patients undergoing mastectomy: long-term results. J Am Coll Surgeons 2014; 218(4): 819–824. doi: 10.1016/j.jamcollsurg.2013.12.041.

Vila J, Garcia-Etienne CA, Vavassori A, Gentilini O. Conservative surgery for ipsilateral breast tumor recurrence. J Surg Oncol 2014; 110(1): 62–67. doi: 10.1002/jso.23629.

Rietjens M, De Lorenzi F, Rossetto F, Brenelli F, Manconi A, Martella S, Intra M, Venturino M, Lohsiriwat V, Ahmed Y, Petit JY. Safety of fat grafting in secondary breast reconstruction after cancer. J Plast Reconstr Aes 2011; 64(4): 477–484. doi: 10.1016/j.bjps.2010.06.024.

Lohsiriwat V, Curigliano G, Rietjens M, Goldhirsch A, Petit JY. Autologous fat transplantation in patients with breast cancer: “silencing” or “fueling” cancer recurrence? Breast J 2011; 20(4): 351–357. doi: 10.1016/j.breast.2011.01.003.

Semprini G, Cattin F, Zanin C, Lazzaro L, Cedolini C, Valenti L, Parodi PC. About locoregional recurrence risk after lipofilling in breast cancer patients: our experience. Minerva Chir 2014; 69(2): 91–96.

Brenelli F, Rietjens M, De Lorenzi F, Pinto-Neto A, Rossetto F, Martella S, Rodrigues JR, Barbalho D. Oncological safety of autologous fat grafting after breast conservative treatment: a prospective evaluation. Breast J 2014; 20(2): 159–165. doi: 10.1111/tbj.12225.

Petit JY, Botteri E, Lohsiriwat V, Rietjens M, De Lorenzi F, Garusi C, Rossetto F, Martella S, Manconi A, Bertolini F, Curigliano G, Veronesi P, Santillo B, Petit JY. Locoregional recurrence risk after lipofilling in breast cancer patients. Ann Oncol 2012; 23(3): 582– 588. doi: 10.1093/annonc/mdr158.

Riggio E, Bordoni D, Nava MB. Oncologic surveillance of breast cancer patients after lipofilling. Aesthet Plast Surg 2013; 37(4): 728–735. doi: 10.1007/s00266-013-0166-5.

Zhao J, Yi C, Guo S. Research progress in adipose derived stem cells’ role in autologous fat transplantation. Chin J Med Aesthet Cosmetol 2013; 19(3): 238–240.

Cervelli V, Gentile P, De Angelis B, Calabrese C, Di Stefani A, Scioli MG, Curcio BC, Felici M, Oriandi A. Application of enhanced stromal vascular fraction and fat grafting mixed with PRP in post-traumatic lower extremity ulcers. Stem Cell Res 2011; 6(2): 103–111. doi: 10.1016/j.scr.2010.11.003.

Gentile P, Orlandi A, Scioli MG, Di Pasquali C, Bocchini I, Curcio BC, Floris M, Fiaschetti V, Floris R, Cervelli V. A comparative translational study: the combined use of enhanced stromal vascular fraction and platelet-rich plasma improves fat grafting maintenance in breast reconstruction. Stem Cell Trans Med 2012; 1(4): 341–351. doi: 10.5966/sctm.2011-0065.

Gutowski KA. Current applications and safety of autologous fat grafts: a report of the ASPS Fat Graft Task Force. Plast Reconstr Surg 2009; 124(1): 272–280. doi: 10.1097/PRS.0b013e3181a09506.

Weiler-Mithoff E, Cano PR, Calabrese C, Hedrick M, Lehr A, Milstein A. Cell-enhanced reconstruction after breast conservation therapy: a proven technique. Cancer Res 2009; 69(S24): 4123. doi: 10.1158/0008-5472.SABCS-09-4123.

Pérez-Cano R, Vranckx JJ, Lasso JM, Calabrese C, Merck B, Mistein AM, Sassoon E, Delay E, Weller-Mithoff E. Prospective trial of adipose-derived regenerative cell (ADRC)-enriched fat grafting for partial mastectomy defects: the RESTORE-2 trial. Eur J Surg Oncol 2012; 38(5): 382–389. doi: 10.1016/j.ejso.2012.02.178.

Techanukul T, Lohsiriwat V. Stem cell and tissue engineering in breast reconstruction. Gland Surg 2014; 3(1): 55–61. doi: 10.3978/j.issn.2227-684X.2014.02.11.

Kølle SFT, Fischer-Nielsen A, Mathiasen AB, Elberg JJ, Oliveri RS, Glovinski PV, Kastrup J, Kirchhoff M, Rasmussen BS, Talman ML, Thomsen C, Dickmeiss E, Drzewiecki KT. Enrichment of autologous fat grafts with ex-vivo expanded adipose tissue-derived stem cells for graft survival: a randomised placebo-controlled trial. Lancet 2003; 382(9898): 1113–1120. doi: 10.1016/S0140-6736(13)61410-5.

Kilroy GE, Foster SJ, Wu X, Ruiz J, Sherwood S, Heifetz A, Ludlow JW, Stricker DM, Potiny S, Green P, Halvorsen YDC, Cheatham B, Storms WR, Gimble MJ. Cytokine profile of human adipose-derived stem cells: expression of angiogenic, hematopoietic, and pro-inflammatory factors. J Cell Physiol 2007; 212(3): 702–709. doi: 10.1002/jcp.21068.

Kuhbier JW, Bucan V, Reimers K, Strauss S, Lazaridis A, Jahn S, Radtke C, Vogt PM. Observed changes in the morphology and phenotype of breast cancer cells in direct co-culture with adipose-derived stem cells. Plast Reconstr Surg 2014; 134(3): 414–423. doi: 10.1097/PRS.0000000000000525.

Eterno V, Zambelli A, Pavesi L, Villani L, Zanini V, Petrolo G, Manera S, Tuscano A, Amato A. Adipose-derived mesenchymal stem cells (ASCs) may favour breast cancer recurrence via HGF/c-Met signaling. Oncotarget 2013; 5(3): 613–633. doi: 10.18632/oncotarget.1359.

Chandler EM, Seo BR, Califano JP, Eguiliz RCA, Lee JS, Yoon CJ, Tims DT, Wang JX, Cheng L, Mohanan S, Buckley MR, Cohen I, Nikitin AU, William RM, Gourdon D, Reinhart-King CA, Fischbach C. Implanted adipose progenitor cells as physicochemical regulators of breast cancer. PNAS 2012; 109(25): 9786–9791. doi: 10.1073/pnas.1121160109.



  • There are currently no refbacks.

Copyright (c) 2018 Xingzi Liu, Jing Han

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.