The Clinical Characteristics and Incidence of Pulmonary Tuberculosis of 7632 HIV Patients in Yunnan Province from 2005 to 2017

Qin Li (Department of Basic Theory of Traditional Chinese Medicine, Basic Medical College, Yunnan University of Traditional Chinese Medicine; Central laboratory, The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Postdoctoral Research Station of Yunnan Provincial Hospital of Traditional Chinese Medicine)
Weibo Wen (Central laboratory, The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Postdoctoral Research Station of Yunnan Provincial Hospital of Traditional Chinese Medicine)
Li Wang (Chinese Medicine Research Center for AIDS, Yunnan Academy of Chinese Medicine)
Fang Fang (Central laboratory, The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Postdoctoral Research Station of Yunnan Provincial Hospital of Traditional Chinese Medicine)
Fang Ye (AIDS Management Office, Linxiang Hospital of Traditional Chinese Medicine)
Juexuan Wang (Department of Basic Theory of Traditional Chinese Medicine, Basic Medical College, Yunnan University of Traditional Chinese Medicine)

Abstract


Objective: To analyze the age and gender distribution characteristics of 7,632 HIV/AIDS patients at the onset of HIV infection-related high-risk intravenous drug abuse and sexual contact in Yunnan province. Methods: Data were collected from the database of Chinese Medicine Treatment of AIDS Pilot Project in Yunnan province. Gender, age and demographics of HIV/AIDS patients were analyzed. Results: The patients were almost in relatively high educational background. The number of male intravenous drug users (12.90%) was more than female, and the earliest average age was 10-14 years. The percentages of men in 10-19 years and 35-59 years were more than that of women. No obvious difference was found in heterosexual sexual contact in both men (48.11%) and women (51.89%), and the earliest ages was 15-19 years in males and 10-14 years in females. The percentage of males at 10-34 years old was less than that of females, just opposite to the age of 35-85 years. Homosexual contact was more in males (92.73%) than that in females (7.27%). The earliest homosexual sexual contact associated with HIV infection was 15-19 years in males and 25-29 years in females. Among 128 AIDS patients with pulmonary tuberculosis infection, intravenous drug abuse accounted for the highest proportion (76.56%) of the three high-risk behaviors related to HIV infection. Conclusions: Reducing risk behaviors and preventing intravenous drug abuse could be effective in preventing AIDS. Compared with other high-risk behaviors, patients with intravenous drug use and AIDS are at greater risk of contracting tuberculosis.


Keywords


Yunnan province; HIV/AIDS; High-risk behavior; Age; Gender

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References


[1] Zhang T, Jia M, Luo H, Zhou Y, Wang N. Study on a HIV/AIDS model with application to Yunnan province, China. Appl Math Model. 2011; 35: 4379-4392.

[2] Xiao Y, Kristensen S, Sun J, Lu L, Vermund SH. Expansion of HIV/AIDS in China: Lessons from Yunnan Province. Soc Sci Med. 2007; 64: 665-675.

[3] Beyrer C, Razak MH, Lisam K, Chen J, Lui W, Yu XF. Overland heroin trafficking routes and HIV-1 spread in south and southeast Asia. AIDS. 2000; 14: 75-83.

[4] Deng R, Li J, Sringernyuang L, Zhang K. Drug abuse, HIV/AIDS and stigmatisation in a Dai community in Yunnan, China. Soc Sci Med. 2007; 64: 1560-1571.

[5] Zhang C, Yang R, Xia X, et al. High prevalence of HIV-1 and hepatitis C virus coinfection among injection drug users in the southeastern region of Yunnan, China. J Acquir Immune Defic Syndr. 2002; 29: 191-196.

[6] Chen X, Zhu L, Zhou YH, et al. Factors associated with needle sharing among people who inject drugs in Yunnan, China: a combined network and regression analysis. Infect Dis Poverty. 2016; 5: 73.

[7] Yang S, Chiu APY, Lin Q, et al. HIV epidemics in Shenzhen and Chongqing, China. PLoS One. 2018; 13: e0192849.

[8] Kesari SP, Basnett B, Chettri A. Spectrum of Tuberculous Infection in Patients Suffering from HIV/AIDS and Its Correlation with CD-4 Counts: A Retrospective Study from Sikkim. Indian J Otolaryngol Head Neck Surg. 2019;71(2):167-171.

[9] Vechi HT, Theodoro RC, de Oliveira AL, et al. Invasive fungal infection by Cryptococcus neoformans var. grubii with bone marrow and meningeal involvement in a HIV-infected patient: a case report. BMC Infect Dis.2019;19(1):220.

[10] Zhang H, Teng T, Lu H, et al. Poppers use and risky sexual behaviors among men who have sex with men in Beijing, China. Drug Alcohol Depend. 2016; 160: 42-48.

[11] Hei FX, Wang L, Qin QQ, et al. [Epidemic characteristics of HIV/AIDS among men who have sex with men from 2006 to 2010 in China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2012; 33:67-70.

[12] Oster AM, Johnson CH, Le BC, et al. Trends in HIV prevalence and HIV testing among young MSM: five United

[13] States cities, 1994-2011. AIDS Behav. 2014; 18 Suppl 3: S237-247.

[14] Outlaw AY, Phillips G, 2nd, Hightow-Weidman LB, et al. Age of MSM sexual debut and risk factors: results from a multisite study of racial/ethnic minority YMSM living with HIV. AIDS Patient Care STDS. 2011; 25 Suppl 1: S23-29.

[15] Budhwani H, Hearld KR, Barrow G, Peterson SN, Walton Levermore K. A comparison of younger and older men who have sex with men using data from Jamaica AIDS Support for Life: characteristics associated with HIV status. Int J STD AIDS. 2016;27(9):769-75.

[16] Li YF, Wang YM, Zhang RR, et al. [Analysis on accuracy and influencing factors of oral fluid-based rapid HIV self-testing among men who have sex with men]. Zhonghua Liu Xing Bing Xue Za Zhi. 2016; 37: 72-75.

[17] Chen M, Jia MH, Ma YL, et al. The changing HIV-1 genetic characteristics and transmitted drug resistance among recently infected population in Yunnan, China. Epidemiol Infect. 2018; 146: 775-781.

[18] Chow EP, Gao L, Chen L, Jing J, Zhang L. Shifting Patterns of the HIV Epidemic in Southwest China: A Case Study Based on Sentinel Surveillance, 1995-2012. AIDS Patient Care STDS. 2015; 29: 314-320.

[19] Chu TX, Levy JA. Injection drug use and HIV/AIDS transmission in China. Cell Res. 2005; 15: 865-869.

[20] Wang B, Liang Y, Feng Y, et al. Prevalence of human immunodeficiency virus 1 infection in the last decade among entry travelers in Yunnan Province, China. BMC Public Health. 2015; 15: 362.

[21] Armstrong G, Jorm AF, Samson L, et al. Association of depression, anxiety, and suicidal ideation with high-risk behaviors among men who inject drugs in Delhi, India. J Acquir Immune Defic Syndr. 2013; 64: 502-510.

[22] Armstrong G, Nuken A, Medhi GK, et al. Injecting drug use in Manipur and Nagaland, Northeast India: injecting and sexual risk behaviours across age groups. Harm Reduct J. 2014; 11: 27.

[23] Miller CL, Wood E, Spittal PM, et al. The future face of

[24] coinfection: prevalence and incidence of HIV and hepatitis C virus coinfection among young injection drug users. J Acquir Immune Defic Syndr. 2004; 36: 743-749.

[25] Shafer KP, Hahn JA, Lum PJ, Ochoa K, Graves A, Moss A. Prevalence and correlates of HIV infection among young injection drug users in San Francisco. J Acquir Immune Defic Syndr. 2002; 31: 422-431.

[26] Des Jarlais DC, Arasteh K, McKnight C, Hagan H, Perlman DC, Semaan S. Associations between herpes simplex virus type 2 and HCV With HIV among injecting drug users in New York City: the current importance of sexual transmission of HIV. Am J Public Health. 2011; 101: 1277-1283.

[27] Jenness SM, Neaigus A, Hagan H, Murrill CS, Wendel T. Heterosexual HIV and sexual partnerships between injection drug users and noninjection drug users. AIDS Patient Care STDS. 2010; 24: 175-181.

[28] Lieb S, Rosenberg R, Arons P, et al. Age shift in patterns of injection drug use among the HIV/AIDS population in Miami-Dade County, Florida. Subst Use Misuse. 2006; 41: 1623-1635.

[29] Klevens RM, Jones SE, Ward JW, Holtzman D, Kann L. Trends in Injection Drug Use Among High School Students, U.S., 1995–2013. Am J Prev Med. 2016; 50: 40-46.

[30] Karmacharya D, Yu D, Dixit S, et al. A study of the prevalence and risk factors leading to HIV infection among a sample of street children and youth of Kathmandu. AIDS Res Ther. 2012; 9: 25.

[31] Neupane SR, Mishra SR, Adhikari S, Poudyal AK. Socio demographic correlates of injection drug use among male drug users: a cross sectional study in Nepal. J Community Health. 2014; 39: 1124-1132.

[32] Hadland SE, Marshall BD, Kerr T, Zhang R, Montaner JS, Wood E. A comparison of drug use and risk behavior profiles among younger and older street youth. Subst Use Misuse. 2011; 46: 1486-1494.

[33] Lai S, Chen J, Celentano D, et al. Adoption of injection practices in heroin users in Guangxi Province, China. J Psychoactive Drugs. 2000; 32: 285-292.

[34] Wickersham JA, Loeliger KB, Marcus R, Pillai V, Kamarulzaman A, Altice FL. Patterns of substance use and correlates of lifetime and active injection drug use among women in Malaysia. Am J Drug Alcohol Abuse. 2016; 42: 98-110.

[35] Kincaid C, Jones DJ, Sterrett E, McKee L. A review of parenting and adolescent sexual behavior: the moderating role of gender. Clin Psychol Rev. 2012; 32: 177-188.

[36] Martins LB, da Costa-Paiva LH, Osis MJ, de Sousa MH, Pinto Neto AM, Tadini V. [Factors associated with condom use and knowledge about STD/AIDS among teenagers in public and private schools in Sao Paulo, Brazil]. Cad Saude Publica. 2006; 22: 315-323.

[37] Cooper D, Hoffman M, Carrara H, et al. Determinants of sexual activity and its relation to cervical cancer risk among South African women. BMC Public Health. 2007; 7: 341.

[38] Taquette SR, Rodrigues Ade O, Bortolotti LR. [HIV infection in female adolescents: a qualitative study]. Rev Panam Salud Publica. 2015; 37: 324-329.

[39] Pettifor AEabc, van der Straten Aad, Dunbar MSab, Shiboski SCae, Padian NSad. Early age of first sex: a risk factor for HIV infection among women in Zimbabwe.AIDS. 2004; 18: 1435-1442.

[40] McCarrey AC, An Y, Kitner-Triolo MH, Ferrucci L, Resnick SM. Sex Differences in Cognitive Trajectories in Clinically Normal Older Adults. Psychol Aging. 2016.

[41] Talib HJ, Silver EJ, Coupey SM, Bauman LJ. The influence of individual, partner, and relationship factors on HIV testing in adolescents. AIDS Patient Care STDS. 2013; 27: 637-645.

[42] Sheliia GP, Chavchidze AT. [Features of physical and sexual development and reproductive behaviour in female adolescents]. Georgian Med News. 2012: 28-32.

[43] Wilson EC, Chen Yh, Arayasirikul S, et al. Differential HIV risk for racial/ethnic minority trans*female youths and socioeconomic disparities in housing, residential stability, and education. Am J Public Health. 2015;105 (Suppl 3):e41-7.

[44] Brown MJ, Serovich JM, Kimberly JA, Umasabor-Bubu O. Disclosure and Self-Efficacy Among HIV-Positive Men Who Have Sex with Men: A Comparison Between Older and Younger Adults. AIDS Patient Care STDS. 2015; 29: 625-633.

[45] Shao B, Li Y, Yu L, et al. The HIV/AIDS epidemic characteristics in a northeast province of China--men who have sex with men have made a tremendous contribution to the growth of the HIV epidemic. J Infect.2014; 68: 273-280.

[46] O’Cleirigh C, Traeger L, Mayer KH, Magidson JF, Safren SA. Anxiety Specific Pathways to HIV Sexual Transmission Risk Behavior among Young Gay and Bisexual Men. J Gay Lesbian Ment Health. 2013; 17: 314-326.

[47] Williams JK, Wilton L, Magnus M, et al. Relation of Childhood Sexual Abuse, Intimate Partner Violence, and Depression to Risk Factors for HIV Among Black Men Who Have Sex With Men in 6 US Cities. Am J Public Health. 2015; 105: 2473-2481.

[48] Newcomb ME. Moderating effect of age on the association between alcohol use and sexual risk in MSM: evidence for elevated risk among younger MSM. AIDS Behav. 2013; 17: 1746-1754.

[49] Kiros T, Dejen E, Tiruneh M, et al. Magnitude and Associated Factors of Pulmonary Tuberculosis Among HIV/AIDS Patients Attending Antiretroviral Therapy Clinic at Debre Tabor Specialized Hospital, Northwest Ethiopia, 2019. HIV AIDS (Auckl). 2020;12:849-858.

[50] Wu J, Wu S, Liu Q, et al. Association of heme oxygenase-1 single nucleotide polymorphisms with susceptibilitym to tuberculosis in Chinese Han population. J Clin Lab Anal. Jul 2020;34(7):e23276.



DOI: https://doi.org/10.30564/jams.v4i2.3449

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Copyright © 2021 Qin Li, Weibo Wen, Li Wang, Fang Fang, Fang Ye, Juexuan Wang


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